PDF(Pubmed)
Abstract：
Background Pre-eclampsia (PE) is a disorder characterized by hypertension that may occur in a pregnant woman who was normotensive earlier. One of the major factors responsible consists of the inflammatory system being activated with cytokines and chemokines. The normal range of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) varies from 1 to 3 and 90 to 210, respectively. Therefore, this study was conducted to compare PE patients with normotensive pregnant women in relation to their NLR as well as PLR. Methodology From January 1, 2021, to December 31, 2022, a case-control study was conducted in the department of obstetrics and gynecology at a tertiary care center. Based on the inclusion and exclusion criteria, a total of 140 antenatal women were included and divided into a case group consisting of 70 women with PE and a control group involving 70 normotensive pregnant women. A blood sample for complete blood count testing was collected to determine NLR and PLR. Results The mean NLR in the case group and control group was 3.52 ± 1.05 and 3.22 ± 0.88, respectively, with statistically significant results. Additionally, the PLR in the case group was 98.08 ± 18.27, and in the control group, it was 85.25 ± 12.36, having a significant difference between both the groups along with a significant difference in the case group among the severe and non-severe PE. Conclusion In antenatal women, NLR and PLR increase with PE along with an increase in NLR and PLR. Additionally, with the availability of a complete blood count, detecting PE ability markers such as the NLR and PLR will be a significant advantage for managing PE to prevent adverse outcomes.
摘要：
背景技术先兆子痫(PE)是一种以高血压为特征的病症,其可发生在较早血压正常的孕妇中。主要因素之一是炎症系统被细胞因子和趋化因子激活。中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）的正常范围分别从1到3和90到210变化。因此,本研究旨在比较PE患者和血压正常的孕妇的NLR和PLR.方法从2021年1月1日至2022年12月31日，在三级护理中心的妇产科进行了病例对照研究。根据纳入和排除标准，共纳入140名产前妇女,将其分为由70名PE妇女组成的病例组和由70名血压正常孕妇组成的对照组.收集用于全血细胞计数测试的血液样品以确定NLR和PLR。结果病例组和对照组的平均NLR分别为3.52±1.05和3.22±0.88。具有统计学意义的结果。此外,病例组为98.08±18.27,对照组为,为85.25±12.36，两组之间存在显着差异，并且在重度和非重度PE中，病例组之间存在显着差异。结论在产前妇女中,NLR和PLR随着PE的增加以及NLR和PLR的增加而增加。此外,有了全血细胞计数,检测PE能力标志物如NLR和PLR将是管理PE以预防不良结局的显著优势.
