PDF(Pubmed)
Abstract：
UNASSIGNED: To explore the clinical role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in differentiating malignant pleural effusion (MPE) from benign pleural effusion (BPE) in patients with lung cancer.
UNASSIGNED: Over a 8-year period, we retrospectively reviewed PET/CT data of lung cancer patients with pleural effusion, with 237 participants enrolled for analysis. The nature of pleural effusion was confirmed using pleural cytology or biopsy. MPE versus BPE comparison and multiple regression analysis were performed. Receiver operating characteristic (ROC) curve analysis was used for evaluating the diagnostic performance.
UNASSIGNED: Of the 237 participants, 170 had MPEs and 67 had BPEs. Compared with BPEs, MPEs had higher pleural SUVmax and thicker pleura and were more common among non-small cell lung cancers, peripheral tumors, and women (p < 0.05). BPEs had larger and higher 18F-FDG uptake thoracic lymph nodes and more complications of pneumonia (p < 0.05) than MPEs. Multiple regression analysis was used to identify the pleural SUVmax (odds ratio, OR = 38.8), sex (OR = 0.033), and mediastinal lymphoid node size (OR = 0.86) as independent risk factors for MPEs. The sensitivity, specificity, and area under the ROC curve (AUC) in the combined ROC curve analysis by using the three factors were 95.3%, 95.5%, and 0.989, respectively.
UNASSIGNED: 18F-FDG PET/CT integrated imaging is an effective non-invasive method for differential diagnosis of MPE in patients with lung cancer. Pleural SUVmax combined with thoracic lymph nodes and sex has high diagnostic value.
UNASSIGNED: Over a 8-year period, we retrospectively reviewed PET/CT data of lung cancer patients with pleural effusion, with 237 participants enrolled for analysis. The nature of pleural effusion was confirmed using pleural cytology or biopsy. MPE versus BPE comparison and multiple regression analysis were performed. Receiver operating characteristic (ROC) curve analysis was used for evaluating the diagnostic performance.
UNASSIGNED: Of the 237 participants, 170 had MPEs and 67 had BPEs. Compared with BPEs, MPEs had higher pleural SUVmax and thicker pleura and were more common among non-small cell lung cancers, peripheral tumors, and women (p < 0.05). BPEs had larger and higher 18F-FDG uptake thoracic lymph nodes and more complications of pneumonia (p < 0.05) than MPEs. Multiple regression analysis was used to identify the pleural SUVmax (odds ratio, OR = 38.8), sex (OR = 0.033), and mediastinal lymphoid node size (OR = 0.86) as independent risk factors for MPEs. The sensitivity, specificity, and area under the ROC curve (AUC) in the combined ROC curve analysis by using the three factors were 95.3%, 95.5%, and 0.989, respectively.
UNASSIGNED: 18F-FDG PET/CT integrated imaging is an effective non-invasive method for differential diagnosis of MPE in patients with lung cancer. Pleural SUVmax combined with thoracic lymph nodes and sex has high diagnostic value.
摘要：
■探讨18F-脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDGPET/CT）在肺癌患者恶性胸腔积液（MPE）和良性胸腔积液（BPE）鉴别诊断中的临床作用。
■在8年的时间里，回顾性分析肺癌合并胸腔积液患者的PET/CT资料,237名参与者参加了分析。使用胸膜细胞学或活检证实胸腔积液的性质。进行MPE与BPE的比较和多元回归分析。受试者工作特征（ROC）曲线分析用于评估诊断性能。
■在237名参与者中，170人患有MPE，67人患有BPE。与BPE相比，MPEs有较高的胸膜SUVmax和较厚的胸膜，在非小细胞肺癌中更常见，外周肿瘤,和女性（p<0.05）。与MPE相比，BPE具有更大和更高的18F-FDG摄取胸淋巴结和更多的肺炎并发症（p<0.05）。采用多元回归分析确定胸膜SUVmax(比值比，OR=38.8)，性别（OR=0.033），纵隔淋巴结大小(OR=0.86)为MPE的独立危险因素。敏感性,特异性，和ROC曲线下面积(AUC)在联合ROC曲线分析中采用三个因素分别为95.3%,95.5%,和0.989。
■18F-FDGPET/CT综合显像是鉴别肺癌患者MPE的一种有效的非侵入性方法。胸膜SUVmax结合胸部淋巴结及性别具有较高的诊断价值。
■在8年的时间里，回顾性分析肺癌合并胸腔积液患者的PET/CT资料,237名参与者参加了分析。使用胸膜细胞学或活检证实胸腔积液的性质。进行MPE与BPE的比较和多元回归分析。受试者工作特征（ROC）曲线分析用于评估诊断性能。
■在237名参与者中，170人患有MPE，67人患有BPE。与BPE相比，MPEs有较高的胸膜SUVmax和较厚的胸膜，在非小细胞肺癌中更常见，外周肿瘤,和女性（p<0.05）。与MPE相比，BPE具有更大和更高的18F-FDG摄取胸淋巴结和更多的肺炎并发症（p<0.05）。采用多元回归分析确定胸膜SUVmax(比值比，OR=38.8)，性别（OR=0.033），纵隔淋巴结大小(OR=0.86)为MPE的独立危险因素。敏感性,特异性，和ROC曲线下面积(AUC)在联合ROC曲线分析中采用三个因素分别为95.3%,95.5%,和0.989。
■18F-FDGPET/CT综合显像是鉴别肺癌患者MPE的一种有效的非侵入性方法。胸膜SUVmax结合胸部淋巴结及性别具有较高的诊断价值。
