Abstract：
Investigating T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), Galectin 9 (Gal-9), CD160 expression and tumor-infiltrating lymphocytes (TILs) and correlation with clinicopathological characteristics of salivary adenoid cystic carcinoma (SACC).
Sixty cases of SACC were detected by immunohistochemical staining to evaluate TIM-3, Gal-9, and CD160 expression and analyze the correlation between TIM-3, Gal-9, CD160 expression and clinicopathologic features by rank-sum test. The association of TILs with TIM-3, Gal-9, and CD160 expression in SACC stromal was done by Chi-square test.
TIM-3 and CD160 overexpression were correlated with recurrence of SACC (p = 0.029, p = 0.007, respectively). High Gal-9 expression was correlated with pathological classification (p = 0.018). The average percentage of TILs was 18.2% in SACC and most of TILs were more likely to occur in minor salivary glands (p = 0.038). Pairwise positive correlations were observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells as well as in TILs, respectively.
Low density of TILs was characteristic of the SACC microenvironment, with upregulation of TIM-3, Gal-9, and CD160 all occurring. However, TIM-3, Gal-9, and CD160 expression in the stromal dependent on the number of TILs represent potential therapeutic targets in SACC.
Sixty cases of SACC were detected by immunohistochemical staining to evaluate TIM-3, Gal-9, and CD160 expression and analyze the correlation between TIM-3, Gal-9, CD160 expression and clinicopathologic features by rank-sum test. The association of TILs with TIM-3, Gal-9, and CD160 expression in SACC stromal was done by Chi-square test.
TIM-3 and CD160 overexpression were correlated with recurrence of SACC (p = 0.029, p = 0.007, respectively). High Gal-9 expression was correlated with pathological classification (p = 0.018). The average percentage of TILs was 18.2% in SACC and most of TILs were more likely to occur in minor salivary glands (p = 0.038). Pairwise positive correlations were observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells as well as in TILs, respectively.
Low density of TILs was characteristic of the SACC microenvironment, with upregulation of TIM-3, Gal-9, and CD160 all occurring. However, TIM-3, Gal-9, and CD160 expression in the stromal dependent on the number of TILs represent potential therapeutic targets in SACC.
摘要：
目的：研究T细胞免疫球蛋白和含粘蛋白结构域-3（TIM-3），半乳糖凝集素9（Gal-9），目的探讨涎腺腺样囊性癌(SACC)的CD160表达与肿瘤浸润淋巴细胞(TILs)及临床病理特征的关系.
方法：对60例SACC进行免疫组化染色，评价TIM-3、Gal-9、CD160的表达，并采用秩和检验分析TIM-3、Gal-9、CD160的表达与临床病理特征的相关性。SACC基质中TIL与TIM-3、Gal-9和CD160表达的关联通过卡方检验进行。
结果：TIM-3和CD160过表达与SACC的复发相关（分别为p=0.029，p=0.007）。高Gal-9表达与病理分级相关(p=0.018)。SACC中TIL的平均百分比为18.2％，大多数TIL更可能发生在小唾液腺中（p=0.038）。TIM-3、Gal-9和CD160在肿瘤细胞和TILs中的表达呈正相关。分别。
结论：低密度TIL是SACC微环境的特征，TIM-3、Gal-9和CD160均上调。然而,依赖于TIL数目的基质中的TIM-3、Gal-9和CD160表达代表SACC中的潜在治疗靶标。
方法：对60例SACC进行免疫组化染色，评价TIM-3、Gal-9、CD160的表达，并采用秩和检验分析TIM-3、Gal-9、CD160的表达与临床病理特征的相关性。SACC基质中TIL与TIM-3、Gal-9和CD160表达的关联通过卡方检验进行。
结果：TIM-3和CD160过表达与SACC的复发相关（分别为p=0.029，p=0.007）。高Gal-9表达与病理分级相关(p=0.018)。SACC中TIL的平均百分比为18.2％，大多数TIL更可能发生在小唾液腺中（p=0.038）。TIM-3、Gal-9和CD160在肿瘤细胞和TILs中的表达呈正相关。分别。
结论：低密度TIL是SACC微环境的特征，TIM-3、Gal-9和CD160均上调。然而,依赖于TIL数目的基质中的TIM-3、Gal-9和CD160表达代表SACC中的潜在治疗靶标。
