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Abstract：
BACKGROUND: The present study had the objective to describe the molecular prevalence and epidemiological aspects of the human T-lymphotropic virus 2 (HTLV-2) infection in the blood donor population of the Pará state.
METHODS: The present study is a descriptive, retrospective, and cross-sectional review of epidemiological, serological, and molecular data on inapt blood donors in the State Center for Hematology and Hemotherapy from January 2015 to December 2021. The data were digitalized to create a database using the Statistical Package for Social Sciences program. The prevalence of HTLV-2 was calculated based on the total number of donations during the study period. Descriptive frequency was used to analyze the qualitative data.
RESULTS: A total of 665,568 blood donations were made. Out of these, 1884 (0.2%) samples presented serological detection to HTLV and further were evaluated using molecular confirmatory tests. Out of these, 36 samples were positive for HTLV-2 using qPCR Taqman assay based on pol gene region (0.005%). The HTLV-2 was found to be more prevalent in women (63.9%); aged between 39 and 59 years (55.6%); residents of the metropolitan region of Belém (80.6%); with self-declared race as brown (80.6%); individuals who had completed high school (58.6%); and first-time donors (58.3%) CONCLUSION: The present study identified the presence of HTLV-2 (1 HTLV-2 case/20,000 donations; 0.005%) in the specific population of blood donors in Pará state. These findings can contribute to the existing literature on the subject both for specific population groups under study and for understanding the prevalence of HTLV-2 in the general population.
METHODS: The present study is a descriptive, retrospective, and cross-sectional review of epidemiological, serological, and molecular data on inapt blood donors in the State Center for Hematology and Hemotherapy from January 2015 to December 2021. The data were digitalized to create a database using the Statistical Package for Social Sciences program. The prevalence of HTLV-2 was calculated based on the total number of donations during the study period. Descriptive frequency was used to analyze the qualitative data.
RESULTS: A total of 665,568 blood donations were made. Out of these, 1884 (0.2%) samples presented serological detection to HTLV and further were evaluated using molecular confirmatory tests. Out of these, 36 samples were positive for HTLV-2 using qPCR Taqman assay based on pol gene region (0.005%). The HTLV-2 was found to be more prevalent in women (63.9%); aged between 39 and 59 years (55.6%); residents of the metropolitan region of Belém (80.6%); with self-declared race as brown (80.6%); individuals who had completed high school (58.6%); and first-time donors (58.3%) CONCLUSION: The present study identified the presence of HTLV-2 (1 HTLV-2 case/20,000 donations; 0.005%) in the specific population of blood donors in Pará state. These findings can contribute to the existing literature on the subject both for specific population groups under study and for understanding the prevalence of HTLV-2 in the general population.
摘要：
背景：本研究的目的是描述帕拉州供血人群中人类嗜T淋巴细胞病毒2（HTLV-2）感染的分子流行和流行病学方面。
方法：本研究是描述性的，回顾性,和流行病学的横断面审查，血清学,以及2015年1月至2021年12月在国家血液学和血液治疗中心的未接受献血者的分子数据。使用社会科学统计软件包计划将数据数字化以创建数据库。根据研究期间的捐赠总数计算HTLV-2的患病率。采用描述性频率对定性数据进行分析。
结果：共进行了665,568次献血。在这些中，1884（0.2％）样品对HTLV进行了血清学检测，并使用分子确证试验进行了进一步评估。在这些中，使用基于pol基因区域的qPCRTaqman测定,36个样品对HTLV-2呈阳性(0.005%)。发现HTLV-2在女性中更为普遍（63.9％）；年龄在39至59岁之间（55.6％）；贝伦大都市地区的居民（80.6％）；自我宣布种族为棕色（80.6％）；完成高中学业的个人（58.6％）；和首次献血者（58.3％）结论：本研究确定了在0.005％的州献血者中有HTLV-2（1％）。这些发现可以为研究中的特定人群和了解HTLV-2在普通人群中的患病率提供有关该主题的现有文献。
方法：本研究是描述性的，回顾性,和流行病学的横断面审查，血清学,以及2015年1月至2021年12月在国家血液学和血液治疗中心的未接受献血者的分子数据。使用社会科学统计软件包计划将数据数字化以创建数据库。根据研究期间的捐赠总数计算HTLV-2的患病率。采用描述性频率对定性数据进行分析。
结果：共进行了665,568次献血。在这些中，1884（0.2％）样品对HTLV进行了血清学检测，并使用分子确证试验进行了进一步评估。在这些中，使用基于pol基因区域的qPCRTaqman测定,36个样品对HTLV-2呈阳性(0.005%)。发现HTLV-2在女性中更为普遍（63.9％）；年龄在39至59岁之间（55.6％）；贝伦大都市地区的居民（80.6％）；自我宣布种族为棕色（80.6％）；完成高中学业的个人（58.6％）；和首次献血者（58.3％）结论：本研究确定了在0.005％的州献血者中有HTLV-2（1％）。这些发现可以为研究中的特定人群和了解HTLV-2在普通人群中的患病率提供有关该主题的现有文献。
