PDF(Pubmed)
Abstract：
Systemic scedosporiosis is a devastating emerging fungal infection caused by several species of the genus Scedosporium in immunocompetent and immunocompromised individuals. In this study, we compared the virulence of different Scedosporium species in a murine model of systemic scedosporiosis by survival assays, fungal burden and histopathological analysis. We found that mice mortality was species-dependent, S. apiospermum, S. aurantiacum and S. dehoogii were the most virulent species. We also observed the dissemination and invasion of Scedosporium species to the brain, spleen and kidney by colony count and histopathological analysis at different times of infection. Particularly, the brain was the tissue most susceptible to invasion during systemic scedosporiosis. This study shows the virulence and pathophysiology of different Scedosporium species and will be useful in facilitating control and prevention strategies for systemic scedosporiosis.
摘要：
系统性scedosporiosis是一种破坏性的新兴真菌感染，由免疫活性和免疫功能低下的个体中的几种Scedosporium属引起。在这项研究中,我们通过存活试验比较了不同的Scedosporium物种在系统性scedosporiosis小鼠模型中的毒力，真菌负荷和组织病理学分析。我们发现老鼠的死亡率取决于物种，S.apiospermum，乌兰和乌兰是毒力最强的物种。我们还观察到Scedosporium物种向大脑的传播和入侵，脾脏和肾脏在不同感染时间的菌落计数和组织病理学分析。特别是,在全身性scedosporiosis期间，大脑是最容易受到侵袭的组织。这项研究显示了不同Scedosporium物种的毒力和病理生理学，将有助于促进全身性scedosporiosis的控制和预防策略。
