Abstract：
Despite melatonin\'s popularity as a pediatric sleep-aid, little has been investigated around caregivers\' understanding and perception of melatonin use for their dependent. This scoping review analyzes the current literature on pediatric melatonin use, to understand how caregivers\' perceptions around melatonin are shaped by their illness/medication-related beliefs, treatment experience and preferences. A literature search was conducted across Embase, Medline, PsycINFO, PubMed and Scopus, generating 184 results for screening against the inclusion criteria. Nineteen studies were retrieved, comprising of 1561 children and adolescents, aged 8.7 ± 2.3 years (range: 0-44 years), conducted primarily in the United States of America (n = 6), Canada (n = 3) and the Netherlands (n = 3). Studies were evaluated for their study design and caregiver-centered outcomes, encompassing: 1) illness/treatment-related beliefs, 2) treatment satisfaction/effectiveness, 3) treatment preference/acceptability, and 4) impact of child\'s sleep disturbance on caregivers\' quality-of-life. Sleep disturbances necessitating melatonin use occurred alongside congenital/neurodevelopmental comorbidities in 18 studies (95%). Melatonin was commonly associated with \"naturalness\" and \"safety\". Concepts of treatment satisfaction versus effectiveness were minimally differentiated within included studies. Caregivers preferred concurrent use of melatonin and behavioral interventions for management of their dependents\' sleep. Improved sleep in the dependent generally led to better quality-of-life for caregivers and their family.
摘要：
尽管褪黑激素作为儿科睡眠辅助剂很受欢迎，关于护理人员对其依赖者使用褪黑激素的理解和感知的调查很少。这篇范围综述分析了目前关于小儿褪黑素使用的文献，了解护理人员对褪黑激素的看法是如何由他们的疾病/药物相关信念形成的，治疗经验和偏好。在Embase进行了文献检索，Medline,PsycINFO,PubMed和Scopus,生成184个结果，用于根据纳入标准进行筛选。检索到19项研究，由1561名儿童和青少年组成，年龄8.7±2.3岁（范围：0-44岁），主要在美利坚合众国进行(n=6)，加拿大（n=3）和荷兰（n=3）。对研究的研究设计和以照顾者为中心的结果进行了评估，包括：1）与疾病/治疗相关的信念，2）治疗满意度/有效性，3)治疗偏好/可接受性，4)儿童睡眠障碍对护理人员生活质量的影响。在18项研究中，需要使用褪黑激素的睡眠障碍与先天性/神经发育合并症同时发生（95％）。褪黑激素通常与“自然性”和“安全性”相关。在纳入的研究中，治疗满意度与有效性的概念差异最小。护理人员更喜欢同时使用褪黑激素和行为干预来管理其家属的睡眠。受抚养人的睡眠改善通常会提高护理人员及其家人的生活质量。
