PDF(Pubmed)
Abstract：
Tumor-associated macrophage (TAM) affects the intrinsic properties of tumor cells and the tumor microenvironment (TME), which can stimulate tumor cell proliferation, migration, and genetic instability, and macrophage diversity includes the diversity of tumors with different functional characteristics. Macrophages are now a central drug target in various diseases, especially in the TME, which, as \"tumor promoters\" and \"immunosuppressors\", have different responsibilities during tumor development and accompany by significant dynamic alterations in various subpopulations. Remodelling immunosuppression of TME and promotion of pre-existing antitumor immune responses is critical by altering TAM polarization, which is relevant to the efficacy of immunotherapy, and uncovering the exact mechanism of action of TAMs and identifying their specific targets is vital to optimizing current immunotherapies. Hence, this review aims to reveal the triadic interactions of macrophages with programmed death and oncotherapy, and to integrate certain relationships in cancer treatment.
摘要：
肿瘤相关巨噬细胞（TAM）影响肿瘤细胞的内在特性和肿瘤微环境（TME），可以刺激肿瘤细胞增殖，迁移,和遗传不稳定性，巨噬细胞多样性包括具有不同功能特征的肿瘤的多样性。巨噬细胞现在是各种疾病的中心药物靶标，尤其是在TME中,which,作为“肿瘤启动子”和“免疫抑制剂”，在肿瘤发展过程中具有不同的责任，并伴随着各种亚群的显着动态改变。通过改变TAM极化，重塑TME的免疫抑制和促进预先存在的抗肿瘤免疫反应至关重要。这与免疫疗法的疗效有关，发现TAM的确切作用机制并确定其特定靶标对于优化当前的免疫疗法至关重要。因此，这篇综述旨在揭示巨噬细胞与程序性死亡和肿瘤治疗的三重相互作用，并将某些关系整合到癌症治疗中。
