PDF(Pubmed)
Abstract：
The non-therapeutic use of antimicrobials in poultry production contributes to the spread of drug-resistant pathogens in both birds and humans. Antibiotics are known to enhance feed efficiency and promote the growth and weight gain of poultry. New regulatory requirements and consumer preferences have led to a reduced use of antibiotics in poultry production and to the discovery of natural alternatives to antibiotic growth promoters. This interest is not only focused on the direct removal or inhibition of causative microorganisms but also on the prevention of diseases caused by enteric pathogens using a range of feed additives. A group of promising feed additives is composed of short- and medium-chain fatty acids (SCFAs and MCFAs) and their derivatives. MCFAs possess antibacterial, anticoccidial, and antiviral effects. In addition, it has been proven that these acids act in synergy if they are used together with organic acids, essential oils, or probiotics. These fatty acids also benefit intestinal health integrity and homeostasis in broilers. Other effects have been documented as well, such as an increase in intestinal angiogenesis and the gene expression of tight junctions. The aim of this review is to provide an overview of SCFAs and MCFAs as alternatives to antibiotic growth promoters and to summarize the current findings in the literature to show their possible benefits on production, meat quality, and gut health in poultry.
摘要：
在家禽生产中抗微生物剂的非治疗性使用有助于耐药性病原体在鸟类和人类中的传播。已知抗生素可提高饲料效率并促进家禽的生长和体重增加。新的监管要求和消费者偏好已经导致在家禽生产中减少了抗生素的使用,并且发现了抗生素生长促进剂的天然替代品。这种兴趣不仅集中于直接去除或抑制致病微生物,而且集中于使用一系列饲料添加剂预防由肠病原体引起的疾病。一组有前途的饲料添加剂由短链和中链脂肪酸（SCFA和MCFA）及其衍生物组成。MCFAs具有抗菌性，抗球虫,和抗病毒作用。此外,已经证明，如果这些酸与有机酸一起使用，它们会协同作用，精油，或益生菌。这些脂肪酸还有益于肉鸡的肠道健康完整性和体内平衡。其他影响也已记录在案，例如肠道血管生成的增加和紧密连接的基因表达。这篇综述的目的是提供SCFA和MCFA作为抗生素生长促进剂替代品的概述，并总结文献中的当前发现，以显示它们对生产的可能好处。肉质,和家禽的肠道健康。
