PDF(Pubmed)
Abstract：
BACKGROUND: Weight loss is associated with a reduction in all body compartments, including muscle mass (MM), and this effect produces a decrease in function and muscle strength. Our objective was to assess the impact of protein or amino acid supplements on MM loss in middle-aged men (age < 65 years) with severe obesity (BMI > 35 kg/m2) during weight loss.
METHODS: We conducted a single-site randomized controlled trial (Clinicaltrials.gov NCT05143398) with 40 in-patient male subjects with severe obesity. Participants underwent an intervention program consisting of a low-calorie balanced diet and structured physical activity. They were randomly assigned to 4-week treatment groups: (1) control (CTR, N = 10), (2) protein (P, N = 10), (3) branched-chain amino acid (BCAA, N = 10), and (4) essential amino acid mixture with tricarboxylic acid cycle intermediates (PD-E07, N = 10) supplementation.
RESULTS: Following 4 weeks of intervention, all groups showed similar reductions in body weight compared to baseline. When examining the delta values, a notable increase in muscle mass (MM) was observed in the PD-E07 intervention group [MM (kg): 2.84 ± 3.57; MM (%): 3.63 ± 3.14], in contrast to the CTR group [MM (kg): -2.46 ± 3.04; MM (%): -0.47 ± 2.28], with a statistical significance of p = 0.045 and p = 0.023, respectively. However, the MM values for the P group [MM (kg): -2.75 ± 5.98, p = 0.734; MM (%): -0.44 ± 4.02, p = 0.990] and the BCAA group [MM (kg): -1 ± 3.3, p = 0.734; MM (%): 0.34 ± 2.85, p = 0.956] did not exhibit a statistically significant difference when compared to the CTR group.
CONCLUSIONS: Amino acid-based supplements may effectively mitigate the loss of MM typically observed during weight reduction. Further validation through large-scale studies is necessary.
METHODS: We conducted a single-site randomized controlled trial (Clinicaltrials.gov NCT05143398) with 40 in-patient male subjects with severe obesity. Participants underwent an intervention program consisting of a low-calorie balanced diet and structured physical activity. They were randomly assigned to 4-week treatment groups: (1) control (CTR, N = 10), (2) protein (P, N = 10), (3) branched-chain amino acid (BCAA, N = 10), and (4) essential amino acid mixture with tricarboxylic acid cycle intermediates (PD-E07, N = 10) supplementation.
RESULTS: Following 4 weeks of intervention, all groups showed similar reductions in body weight compared to baseline. When examining the delta values, a notable increase in muscle mass (MM) was observed in the PD-E07 intervention group [MM (kg): 2.84 ± 3.57; MM (%): 3.63 ± 3.14], in contrast to the CTR group [MM (kg): -2.46 ± 3.04; MM (%): -0.47 ± 2.28], with a statistical significance of p = 0.045 and p = 0.023, respectively. However, the MM values for the P group [MM (kg): -2.75 ± 5.98, p = 0.734; MM (%): -0.44 ± 4.02, p = 0.990] and the BCAA group [MM (kg): -1 ± 3.3, p = 0.734; MM (%): 0.34 ± 2.85, p = 0.956] did not exhibit a statistically significant difference when compared to the CTR group.
CONCLUSIONS: Amino acid-based supplements may effectively mitigate the loss of MM typically observed during weight reduction. Further validation through large-scale studies is necessary.
摘要：
背景：体重减轻与所有身体隔室的减少有关，包括肌肉质量（MM），这种效应导致功能和肌肉力量下降。我们的目的是评估蛋白质或氨基酸补充剂对重度肥胖（BMI>35kg/m2）的中年男性（年龄<65岁）体重减轻的影响。
方法：我们进行了一项单中心随机对照试验（Clinicaltrials.govNCT05143398），纳入了40名重度肥胖住院男性受试者。参与者接受了一项干预计划，包括低热量均衡饮食和结构化身体活动。他们被随机分配到4周治疗组：（1）对照组（CTR，N=10),(2)蛋白质(P,N=10),（3）支链氨基酸（BCAA，N=10),和(4)补充有三羧酸循环中间体(PD-E07,N=10)的必需氨基酸混合物。
结果：干预4周后，与基线相比,所有组的体重减轻相似.检查delta值时，在PD-E07干预组中观察到肌肉质量（MM）显着增加[MM（kg）：2.84±3.57；MM（％）：3.63±3.14]，对比CTR组[MM(kg):-2.46±3.04;MM(%):-0.47±2.28],统计学意义分别为p=0.045和p=0.023。然而,P组的MM值[MM（kg）：-2.75±5.98，p=0.734；MM（％）：-0.44±4.02，p=0.990]和BCAA组[MM（kg）：-1±3.3，p=0.734；MM（％）：0.34±2.85，p=0.956]与CTR组相比，差异无统计学意义。
结论：基于氨基酸的补充剂可以有效减轻体重减轻过程中常见的MM损失。通过大规模研究进一步验证是必要的。
方法：我们进行了一项单中心随机对照试验（Clinicaltrials.govNCT05143398），纳入了40名重度肥胖住院男性受试者。参与者接受了一项干预计划，包括低热量均衡饮食和结构化身体活动。他们被随机分配到4周治疗组：（1）对照组（CTR，N=10),(2)蛋白质(P,N=10),（3）支链氨基酸（BCAA，N=10),和(4)补充有三羧酸循环中间体(PD-E07,N=10)的必需氨基酸混合物。
结果：干预4周后，与基线相比,所有组的体重减轻相似.检查delta值时，在PD-E07干预组中观察到肌肉质量（MM）显着增加[MM（kg）：2.84±3.57；MM（％）：3.63±3.14]，对比CTR组[MM(kg):-2.46±3.04;MM(%):-0.47±2.28],统计学意义分别为p=0.045和p=0.023。然而,P组的MM值[MM（kg）：-2.75±5.98，p=0.734；MM（％）：-0.44±4.02，p=0.990]和BCAA组[MM（kg）：-1±3.3，p=0.734；MM（％）：0.34±2.85，p=0.956]与CTR组相比，差异无统计学意义。
结论：基于氨基酸的补充剂可以有效减轻体重减轻过程中常见的MM损失。通过大规模研究进一步验证是必要的。
