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Abstract：
BACKGROUND: We visually assessed the research hotspots of familial hypercholesterolemia (FH) using bibliometrics and knowledge mapping in light of the research state and development trend of FH.
METHODS: We employed bibliometric tools, such as CiteSpace and the alluvial generator, to illustrate the scientific accomplishments on FH by extracting pertinent literature on FH from the Web of Science Core Collection database from January 1, 2002, to December 31, 2022.
RESULTS: A total of 4402 papers in total were selected for study; 29.2% of all articles globally were from the USA, followed by the Netherlands and England. The University of Amsterdam, University of Oslo, and University of Western Australia are the 3 institutions with the most publications in this area. Gerald F. Watts, Raul D. Santos, and John J. P. Kastelein wrote the majority of the pieces that were published. The New England Journal of Medicine, Circulation, and Atherosclerosis were the journals with the greatest number of papers in this field. Prevalence and genetic analysis of FH, proprotein convertase subtilisin/kexin 9 inhibitors, and inclisiran are current research hotspots for the condition. Future research in this area will be focused on gene therapy.
CONCLUSIONS: FH research has shown shows a trend of ascending followed by leveling off. The prevalence and diagnosis of FH, proprotein convertase subtilisin/kexin 9 inhibitors, inclisiran, and gene therapy are current research hotspots. This report may serve as a reference for current research trends.
METHODS: We employed bibliometric tools, such as CiteSpace and the alluvial generator, to illustrate the scientific accomplishments on FH by extracting pertinent literature on FH from the Web of Science Core Collection database from January 1, 2002, to December 31, 2022.
RESULTS: A total of 4402 papers in total were selected for study; 29.2% of all articles globally were from the USA, followed by the Netherlands and England. The University of Amsterdam, University of Oslo, and University of Western Australia are the 3 institutions with the most publications in this area. Gerald F. Watts, Raul D. Santos, and John J. P. Kastelein wrote the majority of the pieces that were published. The New England Journal of Medicine, Circulation, and Atherosclerosis were the journals with the greatest number of papers in this field. Prevalence and genetic analysis of FH, proprotein convertase subtilisin/kexin 9 inhibitors, and inclisiran are current research hotspots for the condition. Future research in this area will be focused on gene therapy.
CONCLUSIONS: FH research has shown shows a trend of ascending followed by leveling off. The prevalence and diagnosis of FH, proprotein convertase subtilisin/kexin 9 inhibitors, inclisiran, and gene therapy are current research hotspots. This report may serve as a reference for current research trends.
摘要：
背景：根据家族性高胆固醇血症（FH）的研究现状和发展趋势，采用文献计量学和知识图谱对FH的研究热点进行直观评估。
方法：我们采用了文献计量工具，例如CiteSpace和冲积物发生器，通过从2002年1月1日至2022年12月31日的WebofScienceCoreCollection数据库中提取有关FH的相关文献来说明FH的科学成就。
结果：共选择4402篇论文进行研究；全球29.2%的论文来自美国，其次是荷兰和英国。阿姆斯特丹大学,奥斯陆大学,和西澳大利亚大学是这一领域出版物最多的3所机构。GeraldF.Watts,RaulD.Santos,JohnJ.P.Kastelein撰写了大部分已发表的作品。新英格兰医学杂志,循环,动脉粥样硬化是该领域论文数量最多的期刊。FH的患病率和遗传分析，前蛋白转化酶枯草杆菌蛋白酶/kexin9抑制剂，和inclisiran是目前该病的研究热点。该领域的未来研究将集中在基因治疗上。
结论：FH研究显示出上升趋势，然后趋于平稳。FH的患病率和诊断，前蛋白转化酶枯草杆菌蛋白酶/kexin9抑制剂，inclisiran,基因治疗是当前的研究热点。本报告可作为当前研究趋势的参考。
方法：我们采用了文献计量工具，例如CiteSpace和冲积物发生器，通过从2002年1月1日至2022年12月31日的WebofScienceCoreCollection数据库中提取有关FH的相关文献来说明FH的科学成就。
结果：共选择4402篇论文进行研究；全球29.2%的论文来自美国，其次是荷兰和英国。阿姆斯特丹大学,奥斯陆大学,和西澳大利亚大学是这一领域出版物最多的3所机构。GeraldF.Watts,RaulD.Santos,JohnJ.P.Kastelein撰写了大部分已发表的作品。新英格兰医学杂志,循环,动脉粥样硬化是该领域论文数量最多的期刊。FH的患病率和遗传分析，前蛋白转化酶枯草杆菌蛋白酶/kexin9抑制剂，和inclisiran是目前该病的研究热点。该领域的未来研究将集中在基因治疗上。
结论：FH研究显示出上升趋势，然后趋于平稳。FH的患病率和诊断，前蛋白转化酶枯草杆菌蛋白酶/kexin9抑制剂，inclisiran,基因治疗是当前的研究热点。本报告可作为当前研究趋势的参考。
