Abstract：
As the most frequent and vulnerable malignancy among women, breast cancer universally manifests a formidable healthcare challenge. From a biological and molecular perspective, it is a heterogenous disease and is stratified based on the etiological factors driving breast carcinogenesis. Notably, genetic predispositions and epigenetic impacts often constitute the heterogeneity of this disease. Typically, breast cancer is classified intrinsically into histological subtypes in clinical landscapes. These stratifications empower physicians to tailor precise treatments among the spectrum of breast cancer therapeutics. In this pursuit, numerous prognostic algorithms are extensively characterized, drastically changing how breast cancer is portrayed. Therefore, it is a basic requisite to comprehend the multidisciplinary rationales of breast cancer to assist the evolution of novel therapeutic strategies. This review aims at highlighting the molecular and genetic grounds of cancer additionally with therapeutic and phytotherapeutic context. Substantially, it also renders researchers with an insight into the breast cancer cell lines as a model paradigm for breast cancer research interventions.
摘要：
作为女性中最常见和最脆弱的恶性肿瘤，乳腺癌普遍表现出巨大的医疗保健挑战。从生物学和分子的角度来看，它是一种异质性疾病，根据驱动乳腺癌发生的病因进行分层。值得注意的是,遗传易感性和表观遗传影响通常构成该疾病的异质性。通常,乳腺癌在临床上本质上分为组织学亚型。这些分层使医生能够在乳腺癌疗法的范围内定制精确的治疗方法。在这种追求中,许多预后算法被广泛地表征，彻底改变了乳腺癌的描述方式。因此,理解乳腺癌的多学科原理以帮助新的治疗策略的发展是一个基本的必要条件.这篇综述旨在强调癌症的分子和遗传基础以及治疗和植物治疗背景。实质上,它还使研究人员深入了解乳腺癌细胞系作为乳腺癌研究干预的模型范例。
