Abstract：
Aquaporin-2 (AQP2) is a member of the aquaporin water channel family. In the kidney, AQP2 is expressed in collecting duct principal cells where it facilitates water reabsorption in response to antidiuretic hormone (arginine vasopressin, AVP). AVP induces the redistribution of AQP2 from intracellular vesicles and its incorporation into the plasma membrane. The plasma membrane insertion of AQP2 represents the crucial step in AVP-mediated water reabsorption. Dysregulation of the system preventing the AQP2 plasma membrane insertion causes diabetes insipidus (DI), a disease characterised by an impaired urine concentrating ability and polydipsia. There is no satisfactory treatment of DI available. This review discusses kinases that control the localisation of AQP2 and points out potential kinase-directed targets for the treatment of DI.
摘要：
水通道蛋白2（AQP2）是水通道蛋白水通道家族的成员。在肾脏，AQP2在收集导管主细胞中表达，它促进水的重吸收以响应抗利尿激素（精氨酸加压素，AVP)。AVP诱导AQP2从细胞内囊泡的再分布及其掺入质膜。AQP2的质膜插入代表了AVP介导的水重吸收的关键步骤。阻止AQP2质膜插入的系统失调会导致尿崩症（DI），一种以尿液浓缩能力受损和多饮为特征的疾病。没有令人满意的DI处理。这篇综述讨论了控制AQP2定位的激酶，并指出了治疗DI的潜在激酶定向靶标。
