Abstract：
Peripheral nerves have limited regeneration ability following nerve injury. Applying growth factors with neurotrophic roles is beneficial for accelerating peripheral nerve regeneration. Here we show that after rat sciatic nerve injury, growth factor amphiregulin (AREG) is upregulated in Schwann cells of sciatic nerves. Elevated AREG stimulates the proliferation and migration of Schwann cells by activating ERK1/2 cascade. Schwann cell-secreted AREG further facilitates the outgrowth of neurites and the elongation of injured axons. Administration of AREG to injured sciatic nerves stimulates the proliferation of Schwann cells to replace lost cell population, encourages the migration of Schwann cells to form cell cords, and facilitates the regrowth of axons. Overall, our results identify AREG as an important neurotrophic factor and thus provide a promising therapeutic avenue towards peripheral nerve injury.
摘要：
周围神经在神经损伤后具有有限的再生能力。应用具有神经营养作用的生长因子有利于促进周围神经再生。在这里，我们显示了大鼠坐骨神经损伤后，生长因子双调蛋白（AREG）在坐骨神经的雪旺细胞中上调。升高的AREG通过激活ERK1/2级联刺激雪旺氏细胞的增殖和迁移。雪旺氏细胞分泌的AREG进一步促进神经突的生长和受损轴突的伸长。对损伤的坐骨神经施用AREG刺激雪旺氏细胞的增殖，以取代丢失的细胞群，促进雪旺氏细胞迁移形成细胞索，促进轴突的再生.总的来说,我们的结果确定AREG是一种重要的神经营养因子,因此为周围神经损伤提供了一个有希望的治疗途径.
