PDF(Pubmed)
Abstract：
Ifosfamide, which is widely used as a chemotherapeutic agent in various kinds of malignancies, sometimes causes neurotoxicity known as ifosfamide-induced encephalopathy (IIE). Herein, we report the case of a three-year-old girl who developed IIE during chemotherapy for Ewing\'s sarcoma and was treated with methylene blue as a prophylactic agent for IIE, after which she continued with ifosfamide and completed treatment without IIE recurrence. This case suggests that methylene blue may be effective in preventing the recurrence of IIE in pediatric patients. Further studies, including clinical trials, are needed to confirm the efficacy and safety of methylene blue in pediatric patients.
摘要：
异环磷酰胺,它被广泛用作各种恶性肿瘤的化疗药物，有时会引起神经毒性，称为异环磷酰胺诱发的脑病（IIE）。在这里，我们报告了一个3岁女孩的病例，她在尤因肉瘤化疗期间发展为IIE，并接受了亚甲蓝作为IIE的预防剂治疗，之后,她继续使用异环磷酰胺并完成治疗,没有IIE复发.这种情况表明亚甲蓝可能有效预防儿科患者IIE的复发。进一步研究,包括临床试验,需要确认亚甲蓝在儿科患者中的疗效和安全性。
