PDF(Pubmed)
Abstract：
Introduction: In the scenario of metal toxicity, aluminum (Al) stands out as a ubiquitous type of metal that can be combined with other elements and form different compounds. Al is widely used daily as an adjuvant in vaccines, antacids, food additives (as components of AI-containing food additives), skin care products, cosmetics, and kitchenware, and can be an element or contaminant present in our daily life. Objective: To present a review of the main deleterious effects of Al on human health. Methods: The search was carried out from September 2022 to February 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2012 to 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusions: A total of 115 files were search returned. Further, 95 articles were evaluated, and 44 were included in this review. Based on the results, measuring Al\'s relevance to health is essential in medicine. Several studies have demonstrated clinical outcomes and metabolic alterations with Al exposure. The tolerable weekly intake established by the European Food Safety Authority (EFSA) of 1 mg Al/kg body weight can be achieved through dietary exposure alone. Proven neurotoxicity in humans is the critical adverse effect of Al. A carcinogenic effect of Al has not been proven so far. Preventive medicine advocates that exposure to Al should be kept as low as possible. Chelating agents, such as calcium disodium ethylene diamine tetraacetic acid and deferoxamine, are options for acute poisoning, and monomethysilanetriol supplementation may be a long-term strategy with chelation potential. Further studies are needed to assess the impacts of Al on human health.
摘要：
简介：在金属毒性的情况下，铝（Al）作为一种普遍存在的金属，可以与其他元素结合并形成不同的化合物。Al每天广泛用作疫苗的佐剂，抗酸剂,食品添加剂（作为含AI食品添加剂的成分），护肤品,化妆品,和厨具，并且可能是我们日常生活中存在的元素或污染物。目的：综述铝对人类健康的主要有害影响。方法：搜索于2022年9月至2023年2月在Scopus进行，PubMed,科学直接，Scielo,和谷歌学者数据库，使用2012年至2023年的科学文章。研究的质量取决于GRADE仪器，并根据Cochrane仪器分析偏倚风险。结果与结论：共检索115个文件。Further,评估了95篇文章，44人被纳入本审查.根据结果,测量Al与健康的相关性在医学中至关重要。一些研究已经证明了铝暴露的临床结果和代谢改变。欧洲食品安全局（EFSA）规定的每周可容忍摄入量为1mgAl/kg体重，可以通过单独的饮食暴露来实现。在人类中证明的神经毒性是Al的关键不利影响。到目前为止，尚未证明Al的致癌作用。预防医学主张应尽可能低的暴露于铝。螯合剂,如乙二胺四乙酸钙二钠和去铁胺，是急性中毒的选择，补充单甲基硅烷三醇可能是具有螯合潜力的长期策略。需要进一步的研究来评估铝对人类健康的影响。
