PDF(Pubmed)
Abstract：
Certain pathogens, due to their adverse effects on the immune reaction, aggravate the course of concomitant heterologous infections. Here we summarize mechanisms by which circoviruses, including the most studied porcine circovirus 2, and other mammalian and avian circoviruses, trigger their own replication and confound the hosts\' immune response. At different stages of infection, from latent state to disease induction, these viruses markedly influence the cellular signaling pathways. Circoviruses have been found to interfere with interferon and proinflammatory cytokine producing and responsive pathways. Apoptotic processes, altered cellular transport and constraint of the mitotic phase all support the viral replication. The cytokine imbalance and lymphocyte depletion, thus the impaired immunity, favors invasion of super- or co-infecting agents, which in concert with circoviruses induce illnesses with increased severity. The information summarized in this review point out the diversity of host and viral factors involved in the mechanisms of disease progression during circovirus infections.
摘要：
某些病原体,由于它们对免疫反应的不利影响，加重伴随的异源感染的过程。在这里，我们总结了圆环病毒的机制，包括研究最多的猪圆环病毒2，以及其他哺乳动物和禽圆环病毒，触发它们自己的复制并混淆宿主的免疫反应。在感染的不同阶段，从潜伏状态到疾病诱导，这些病毒显著影响细胞信号通路。已发现圆环病毒干扰干扰素和促炎细胞因子的产生和反应途径。凋亡过程，改变的细胞运输和有丝分裂期的限制都支持病毒复制。细胞因子失衡和淋巴细胞耗竭，因此受损的免疫力，有利于入侵超级或共感染剂，与圆环病毒一起导致严重程度增加的疾病。这篇综述中总结的信息指出了在圆环病毒感染期间参与疾病进展机制的宿主和病毒因素的多样性。
