PDF(Pubmed)
Abstract：
Virus interference is one of the oldest concepts in immunology. Recent findings indicate that it may depend on the host\'s anti-viral cellular immune surveillance processes, as well as on sequence-specific gene silencing mechanism guided by double-stranded RNA. Other biological events, unrelated to some degree at least from immune-dependent IFN or RNA-dependent viral interference may be at play as well. We discuss these biological mechanisms in the context of of the Systemic Acute Respiratory Syndrome Corona virus2 (SARS-CoV2) virus responsible for Corona Virus Disease 2019 (CoViD-19).
摘要：
病毒干扰是免疫学中最古老的概念之一。最近的研究结果表明，它可能取决于宿主的抗病毒细胞免疫监视过程，以及双链RNA指导的序列特异性基因沉默机制。其他生物活动,至少在某种程度上与免疫依赖性IFN或RNA依赖性病毒干扰无关。我们在负责冠状病毒病2019（CoViD-19）的系统性急性呼吸综合征冠状病毒2（SARS-CoV2）病毒的背景下讨论了这些生物学机制。
