Surgical management of deep dermatophytosis in a patient with CARD9 deficiency.

CARD9 缺乏症患者深部皮肤癣菌病的外科治疗。

• 发表时间: 2023 Jul
• 来源期刊: J Surg Case Rep
• DOI: 10.1093/jscr/rjad388
• PMID: 37426045
• 文章类型: Case Reports
• 作者列表: El Maati M,Berjaou Z,Hammouch Z,Khachani K,Moustakbal I,Meziane M,Ismaili N,Benzekri L,Aoufi S,Mazouz S,Senouci K

关键词: CARD9 mutation; Deep dermatophytosis; mycotic abscesses; scarring alopecia; surgical drainage

Abstract

Deep dermatophytosis is a dermal infection caused by Dermatophytes. It can cause deeper dermal dermatophytosis, Majocchi\'s granuloma, dermatophytic pseudomycetoma or a widespread infection. CARD9 deficiency is a known risk factor in the Mediterranean region, first reported in 1964 in Morocco. We report a case of 23-year-old man with a scarring alopecia who presented with subcutaneous abscesses topped off with a large ringworm infection. Mycotic analysis revealed a Trichophyton Rubrum deep dermatophytosis. The molecular study revealed a CARD9 mutation confirming dermatophytosis with parotid and lymph nodes involvement. The patient underwent successful drainage surgery of the abscesses alongside medical treatment including antifungal agents and he was discharged after an uneventful postoperative course.

摘要

深部皮肤癣菌病是由皮肤癣菌引起的皮肤感染。它会导致更深的皮肤真菌病，Majocchi肉芽肿,皮肤真菌假单胞菌瘤或广泛感染。CARD9缺乏是地中海地区已知的危险因素，1964年在摩洛哥首次报道。我们报告了一例23岁的疤痕脱发患者，其皮下脓肿伴大型癣感染。真菌分析显示红色毛癣菌深部皮肤癣菌病。分子研究显示CARD9突变，证实腮腺和淋巴结受累的皮肤癣菌病。该患者成功进行了脓肿引流手术，并进行了包括抗真菌药物在内的药物治疗，术后顺利出院。