PDF(Pubmed)
Abstract：
In the course of SRY-box transcription factor 6 (SOX6) expression profiling in human embryonic tissue, SOX 6 was found to be highly expressed in the notochord, based on the findings of immunohistochemistry (IHC). Sox6 is also expressed in the neural tube and the distribution of SOX6 is located in the ventral and dorsal zones of the neural tube. In contrast to the findings that SOX6-positive cells were located on the floor plate of the neural tube, OLIG2- and NKX2.2-expressing cells were lacking on the floor plate of the neural tube, and their expression was restricted only to the ventral zone of the neural tube. The expression patterns of SOX9 were similar to those of OLIG2 and NKX2.2 in the neural tube. NKX2.2 and OLIG2 are not expressed in the notochord, but SOX9 and SOX6 are. Because Sox6 is highly expressed in the notochord, the present study investigated whether or not SOX6 is an immunohistochemical marker for the pathologic diagnosis of chordoma, a neoplasm derived from the notochord. IHC revealed that chordoma was strongly positive for SOX6 in two cases of chordoma, one of which occurred in the sacrococcygeal region and another that developed at the base of the skull, suggesting that SOX6 is a useful marker for the histopathologic diagnosis of chordoma.
摘要：
在人胚胎组织中SRY-box转录因子6(SOX6)表达谱的过程中,发现SOX6在脊索中高度表达，基于免疫组织化学（IHC）的发现。Sox6也在神经管中表达，SOX6的分布位于神经管的腹侧和背侧区。与SOX6阳性细胞位于神经管底板上的发现相反，神经管底板上缺乏表达OLIG2和NKX2.2的细胞，它们的表达仅限于神经管的腹侧区。SOX9在神经管中的表达模式与OLIG2和NKX2.2相似。NKX2.2和OLIG2在脊索中不表达，但是SOX9和SOX6是.因为Sox6在脊索中高度表达，本研究调查了SOX6是否是脊索瘤病理诊断的免疫组织化学标记，来源于脊索的肿瘤。IHC显示，在2例脊索瘤中，脊索瘤对SOX6呈强烈阳性，其中一个发生在骶尾部，另一个发生在颅底，提示SOX6是脊索瘤组织病理学诊断的有用标记物。
