PDF(Pubmed)
Abstract：
UNASSIGNED: To report the long-time success rate of XEN 45 gel stent implantation in a Scandinavian population.
UNASSIGNED: This was a retrospective single-center analysis of all patients undergoing XEN 45 stent surgery between December 2015 and May 2017. The main outcome was success rate according to several definitions of success. Subgroup analysis was performed. Secondary outcomes were change in intraocular pressure (IOP) and number of IOP-lowering agents. Need for secondary glaucoma surgery, needling rate and complications were recorded.
UNASSIGNED: A total of 103 eyes could be evaluated after four years. Mean age was 70.6 years. Primary open-angle glaucoma (POAG) accounted for 46.6% and exfoliative glaucoma (PEXG) for 39.8%. Mean IOP dropped from 24.0 to 15.9 mmHg (p<0.001) and IOP-lowering agents from 3.5 to 1.5 (p<0.001). The success rate with individual target pressures after four years was 43.7%. Secondary glaucoma surgery was performed in 45 (43.7%) of cases. Combined cases (n=12) were not statistically different to stand-alone procedures (p=0.28). No difference between PEXG and POAG could be detected (p=0.44). During the learning curve, stent misplacement was common and resulted in worse outcome for less experienced surgeons.
UNASSIGNED: The overall success rate of XEN 45 gel stent surgery in the present cohort is relatively low in a long-time follow-up under the given circumstances if all initial patients are included to follow-up. The influence of the surgeon\'s learning curve is obvious, and improvement in success can be expected when used by experienced and high-volume surgeons. No significant differences were found in PEXG compared to POAG or in XEN surgery combined with cataract surgery compared to stand-alone.
UNASSIGNED: This was a retrospective single-center analysis of all patients undergoing XEN 45 stent surgery between December 2015 and May 2017. The main outcome was success rate according to several definitions of success. Subgroup analysis was performed. Secondary outcomes were change in intraocular pressure (IOP) and number of IOP-lowering agents. Need for secondary glaucoma surgery, needling rate and complications were recorded.
UNASSIGNED: A total of 103 eyes could be evaluated after four years. Mean age was 70.6 years. Primary open-angle glaucoma (POAG) accounted for 46.6% and exfoliative glaucoma (PEXG) for 39.8%. Mean IOP dropped from 24.0 to 15.9 mmHg (p<0.001) and IOP-lowering agents from 3.5 to 1.5 (p<0.001). The success rate with individual target pressures after four years was 43.7%. Secondary glaucoma surgery was performed in 45 (43.7%) of cases. Combined cases (n=12) were not statistically different to stand-alone procedures (p=0.28). No difference between PEXG and POAG could be detected (p=0.44). During the learning curve, stent misplacement was common and resulted in worse outcome for less experienced surgeons.
UNASSIGNED: The overall success rate of XEN 45 gel stent surgery in the present cohort is relatively low in a long-time follow-up under the given circumstances if all initial patients are included to follow-up. The influence of the surgeon\'s learning curve is obvious, and improvement in success can be expected when used by experienced and high-volume surgeons. No significant differences were found in PEXG compared to POAG or in XEN surgery combined with cataract surgery compared to stand-alone.
摘要：
■报告斯堪的纳维亚人群中XEN45凝胶支架植入的长期成功率。
■这是对2015年12月至2017年5月期间接受XEN45支架手术的所有患者的回顾性单中心分析。根据成功的几种定义，主要结果是成功率。进行亚组分析。次要结果是眼内压（IOP）和降低IOP的药物数量的变化。需要继发性青光眼手术，记录针刺率和并发症。
■四年后总共可以评估103只眼。平均年龄为70.6岁。原发性开角型青光眼（POAG）占46.6％，剥脱性青光眼（PEXG）占39.8％。平均IOP从24.0降至15.9mmHg（p<0.001），降低IOP的药物从3.5降至1.5（p<0.001）。四年后个体目标压力的成功率为43.7％。45例（43.7％）进行了继发性青光眼手术。合并病例（n=12）与独立手术无统计学差异（p=0.28）。在PEXG和POAG之间没有检测到差异(p=0.44)。在学习曲线期间，支架错位是常见的，并导致经验不足的外科医生的预后较差。
■如果将所有初始患者纳入随访，在给定情况下，在长期随访中，本队列中XEN45凝胶支架手术的总体成功率相对较低。外科医生的学习曲线的影响是显而易见的，当经验丰富和高容量的外科医生使用时，可以预期成功的改善。与POAG相比，PEXG或与单独的白内障手术相比，在XEN手术联合白内障手术中没有发现显着差异。
■这是对2015年12月至2017年5月期间接受XEN45支架手术的所有患者的回顾性单中心分析。根据成功的几种定义，主要结果是成功率。进行亚组分析。次要结果是眼内压（IOP）和降低IOP的药物数量的变化。需要继发性青光眼手术，记录针刺率和并发症。
■四年后总共可以评估103只眼。平均年龄为70.6岁。原发性开角型青光眼（POAG）占46.6％，剥脱性青光眼（PEXG）占39.8％。平均IOP从24.0降至15.9mmHg（p<0.001），降低IOP的药物从3.5降至1.5（p<0.001）。四年后个体目标压力的成功率为43.7％。45例（43.7％）进行了继发性青光眼手术。合并病例（n=12）与独立手术无统计学差异（p=0.28）。在PEXG和POAG之间没有检测到差异(p=0.44)。在学习曲线期间，支架错位是常见的，并导致经验不足的外科医生的预后较差。
■如果将所有初始患者纳入随访，在给定情况下，在长期随访中，本队列中XEN45凝胶支架手术的总体成功率相对较低。外科医生的学习曲线的影响是显而易见的，当经验丰富和高容量的外科医生使用时，可以预期成功的改善。与POAG相比，PEXG或与单独的白内障手术相比，在XEN手术联合白内障手术中没有发现显着差异。
