PDF(Pubmed)
Abstract：
UNASSIGNED: Pseudomonas citronellolis is an unusual pathogen in humans and has not been extensively described in the scientific literature. Herein, we present a case of bacteremia and septic shock due to Pseudomonas citronellolis following Campylobacter species gastroenteritis in a patient with immunosuppression.
UNASSIGNED: An 80-year-old man with myeloproliferative disorder on ruxolitinib presented with several days of worsening abdominal pain, which rapidly developed into septic shock with multi-organ failure and explosive diarrhea. Gram-negative bacilli observed on Gram staining of his blood culture broth were later identified as Pseudomonas citronellolis and Bacteroides thetaiotaomicron . Repeated abdominal imaging revealed no evidence of intestinal perforation or megacolon. In addition, stool PCR was positive for Campylobacter species. His clinical course improved after 14 days of meropenem with complete resolution of his symptoms and organ failure.
UNASSIGNED: P. citronellolis is a rare infection in humans. We postulate that Janus Associated Kinase (JAK) inhibition in myeloproliferative disorders heightened this patient\'s risk of bacterial translocation and severe illness in the setting of Campylobacter gastroenteritis. P. citronellolis may be identified more frequently as a pathogen in humans as more advanced diagnostic technologies become increasingly available in clinical microbiology.
UNASSIGNED: An 80-year-old man with myeloproliferative disorder on ruxolitinib presented with several days of worsening abdominal pain, which rapidly developed into septic shock with multi-organ failure and explosive diarrhea. Gram-negative bacilli observed on Gram staining of his blood culture broth were later identified as Pseudomonas citronellolis and Bacteroides thetaiotaomicron . Repeated abdominal imaging revealed no evidence of intestinal perforation or megacolon. In addition, stool PCR was positive for Campylobacter species. His clinical course improved after 14 days of meropenem with complete resolution of his symptoms and organ failure.
UNASSIGNED: P. citronellolis is a rare infection in humans. We postulate that Janus Associated Kinase (JAK) inhibition in myeloproliferative disorders heightened this patient\'s risk of bacterial translocation and severe illness in the setting of Campylobacter gastroenteritis. P. citronellolis may be identified more frequently as a pathogen in humans as more advanced diagnostic technologies become increasingly available in clinical microbiology.
摘要：
■香型假单胞菌是人类中不常见的病原体，在科学文献中尚未广泛描述。在这里，我们介绍了1例免疫抑制患者在弯曲杆菌型胃肠炎后因香型假单胞菌引起的菌血症和感染性休克。
一名80岁患有骨髓增殖性疾病的男子服用鲁索利替尼后出现几天的腹痛恶化，迅速发展为脓毒性休克并伴有多器官功能衰竭和爆发性腹泻。在他的血液培养肉汤的革兰氏染色中观察到的革兰氏阴性杆菌后来被鉴定为香茅假单胞菌和拟杆菌。重复的腹部成像显示没有肠穿孔或巨结肠的证据。此外,粪便PCR对弯曲杆菌呈阳性.美罗培南14天后，他的临床病程有所改善，症状和器官衰竭完全缓解。
■P.香茅是人类罕见的感染。我们假设骨髓增殖性疾病中的Janus相关激酶（JAK）抑制增加了该患者在弯曲杆菌胃肠炎中细菌易位和严重疾病的风险。随着更先进的诊断技术在临床微生物学中变得越来越可用，香茅假单胞菌可能更频繁地被鉴定为人类的病原体。
一名80岁患有骨髓增殖性疾病的男子服用鲁索利替尼后出现几天的腹痛恶化，迅速发展为脓毒性休克并伴有多器官功能衰竭和爆发性腹泻。在他的血液培养肉汤的革兰氏染色中观察到的革兰氏阴性杆菌后来被鉴定为香茅假单胞菌和拟杆菌。重复的腹部成像显示没有肠穿孔或巨结肠的证据。此外,粪便PCR对弯曲杆菌呈阳性.美罗培南14天后，他的临床病程有所改善，症状和器官衰竭完全缓解。
■P.香茅是人类罕见的感染。我们假设骨髓增殖性疾病中的Janus相关激酶（JAK）抑制增加了该患者在弯曲杆菌胃肠炎中细菌易位和严重疾病的风险。随着更先进的诊断技术在临床微生物学中变得越来越可用，香茅假单胞菌可能更频繁地被鉴定为人类的病原体。
