Abstract：
Granulomatosis with polyangiitis (GPA) is an autoimmune granulomatous disease of unknown etiology; frequently associated with anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). Although any organ can be involved, prostatic involvement in GPA is very rare. We present a male patient with GPA, 26 years old, with pulmonary manifestations and prostatic involvement who underwent exhaustive evaluation. The patient\'s laboratory tests and imaging scans showed evidence of lesions in multiple areas, including the prostate. Histopathological testing confirmed that the lesions were consistent with granulomatosis with polyangiitis. The patient was treated with oral steroids and rituximab and showed significant improvement. He was later maintained on azathioprine without any relapse.
摘要：
肉芽肿性多血管炎（GPA）是一种病因不明的自身免疫性肉芽肿性疾病；通常与抗蛋白酶3抗中性粒细胞胞浆抗体（PR3-ANCA）相关。虽然任何器官都可以参与，前列腺参与GPA非常罕见。我们提出一名男性患者的GPA,26岁,进行详尽评估的肺部表现和前列腺受累。患者的实验室检查和影像学扫描显示多个区域有病变的证据，包括前列腺.组织病理学检查证实，病变与肉芽肿性多血管炎一致。患者接受口服类固醇和利妥昔单抗治疗，并表现出显着改善。后来他继续服用硫唑嘌呤，没有任何复发。
