PDF(Pubmed)
Abstract：
High-level isolation units (HLIUs) are specially designed facilities for care and management of patients with suspected or confirmed high-consequence infectious diseases (HCIDs), equipped with unique infrastructure and operational features. While individual HLIUs have published on their experiences caring for patients with HCIDs and two previous HLIU consensus efforts have outlined key components of HLIUs, we aimed to summarise the existing literature that describes best practices, challenges and core features of these specialised facilities. A narrative review of the literature was conducted using keywords associated with HLIUs and HCIDs. A total of 100 articles were used throughout the manuscript from the literature search or from alternate methods like reference checks or snowballing. Articles were sorted into categories (eg, physical infrastructure, laboratory, internal transport); for each category, a synthesis of the relevant literature was conducted to describe best practices, experiences and operational features. The review and summary of HLIU experiences, best practices, challenges and components can serve as a resource for units continuing to improve readiness, or for hospitals in early stages of developing their HLIU teams and planning or constructing their units. The COVID-19 pandemic, a global outbreak of mpox, sporadic cases of viral haemorrhagic fevers in Europe and the USA, and recent outbreaks of Lassa fever, Sudan Ebolavirus, and Marburg emphasise the need for an extensive summary of HLIU practices to inform readiness and response.
摘要：
高级隔离单位（HLIUs）是专门设计的设施，用于护理和管理疑似或确诊的高危重传染病（HCID）患者。配备独特的基础设施和操作功能。虽然个别HLIUs发表了他们照顾HCID患者的经验，并且先前的两次HLIU共识努力概述了HLIUs的关键组成部分，我们旨在总结描述最佳实践的现有文献，这些专业设施的挑战和核心特征。使用与HLIU和HCID相关的关键词对文献进行了叙述性回顾。通过文献检索或参考检查或滚雪球等其他方法，在整个手稿中总共使用了100篇文章。文章被分类(例如，物理基础设施，实验室,内部运输)；对于每个类别，对相关文献进行了综合，以描述最佳实践，经验和操作特点。回顾和总结HLIU的经验，最佳实践,挑战和组件可以作为单位继续提高战备状态的资源，或医院在发展他们的HLIU团队和规划或建设他们的单位的早期阶段。COVID-19大流行，全球爆发的水痘,欧洲和美国的病毒性出血热散发病例，以及最近爆发的拉沙热，苏丹埃博拉病毒，和马尔堡强调需要广泛总结HLIU做法，以告知准备和响应。
