Abstract：
Although the toxicity of microplastics (MPs) and pesticides has recently been described, the possible effects of combining these pollutants are poorly understood. Thus, we evaluated the potential impact of exposure to polyethylene MP (PE-MP) and abamectin (ABM) (alone and combined) in zebrafish. After five days, the combined exposure to MP and ABM decreased the survival rate compared to exposures to individual pollutants. A significant increase in reactive oxygen species (ROS), lipid peroxidation, apoptosis, and impairment in antioxidant response was observed in zebrafish larvae. Morphological changes in the eyes of zebrafish significantly increased in the combined exposure group than in the individual exposure. Furthermore, the bax and p53 expression (specific apoptotic genes) was significantly upregulated after the combined exposure to PE-MP and ABM. So, the synergetic effect of MP and ABM cannot be ignored, and further research on other higher models is required to confirm its consequences.
摘要：
尽管最近已经描述了微塑料（MPs）和农药的毒性，对这些污染物混合的可能影响知之甚少。因此，我们评估了斑马鱼暴露于聚乙烯MP(PE-MP)和阿维菌素(ABM)(单独和联合)的潜在影响.五天后,与暴露于单个污染物相比,联合暴露于MP和ABM降低了存活率.活性氧（ROS）的显着增加，脂质过氧化，凋亡，在斑马鱼幼虫中观察到抗氧化反应的损害。斑马鱼眼睛的形态变化在联合暴露组中比在个体暴露中显着增加。此外，联合暴露于PE-MP和ABM后,bax和p53表达(特异性凋亡基因)显著上调.所以,MP和ABM的协同作用不容忽视，需要进一步研究其他更高的模型来证实其后果。
