METHODS: 32 children with CECTS and 25 age- and gender-matched healthy children were enrolled. All participants were imaged with 3.0-T MRI to acquire the structural and susceptibility-weighted data. The susceptibility-weighted data were processed using STISuite toolbox to obtain QSM. The magnetic susceptibility difference between the two groups was compared using voxel-wise and region of interest methods. Multivariable linear regression, controlling for age, were employed to investigate the associations between the brain magnetic susceptibility and age at onset.
RESULTS: Lower magnetic susceptibility was mainly observed in sensory- and motor-related brain regions in children with CECTS, including bilateral middle frontal gyrus, supplementary motor area, midcingulate cortex, paracentral lobule and precentral gyrus, the magnetic susceptibility of right paracentral lobule, right precuneus and left supplementary motor area were found to have positive correlation with the age at onset.
CONCLUSIONS: This study suggests that the potential iron deficiency in certain brain regions is associated with CECTS, which might be helpful for further illumination of potential pathogenesis mechanism of CECTS.
方法:纳入32名CECTS儿童和25名年龄和性别匹配的健康儿童。所有参与者均使用3.0-TMRI成像,以获取结构和敏感性加权数据。使用STISuite工具箱处理敏感性加权数据以获得QSM。使用逐体素和感兴趣区域方法比较了两组之间的磁化率差异。多变量线性回归,控制年龄,用于研究大脑磁化率与发病年龄之间的关联。
结果:在患有CECTS的儿童中,主要在与感觉和运动相关的大脑区域观察到较低的磁化率,包括双侧额叶中回,辅助电机区域,中扣带皮质,中央旁小叶和中央前回,右中央旁小叶的磁化率,发现右前肌和左补充运动区与发病年龄呈正相关。
结论:这项研究表明,某些脑区的潜在缺铁与CECTS有关,这可能有助于进一步阐明CECTS的潜在发病机制。