Abstract：
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that affects the processing of carbohydrates, proteins, and lipids. In T2DM, metabolic dysregulation occurs through various pathways caused by increased levels of many adipokines and inflammatory chemokines. Impaired insulin-glucose metabolism occurs in tissues. The proteolytic enzyme matriptase is thought to be closely related to glucose metabolism due to its glycolization sites.
OBJECTIVE: Our study aimed to evaluate the correlation between matriptase, a proteolytic enzyme, and metabolic parameters in individuals recently diagnosed with T2DM. We also sought to investigate the potential involvement of matriptase in the development of diabetes.
METHODS: We measured all participants\' metabolic laboratory parameters, including basic biochemical tests, hemograms, high-sensitivity C-reactive protein (hsCRP), and matriptase levels.
RESULTS: Our results showed a significant increase in circulating matriptase levels in individuals with T2DM compared to the control group. Furthermore, individuals with metabolic syndrome had significantly higher matriptase levels than those without in the T2DM and control groups. We also observed that T2DM patients had elevated levels of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), hsCRP, and matriptase, which displayed a positive correlation.
CONCLUSIONS: Our study is the first to report elevated levels of matriptase in individuals with newly diagnosed T2DM and/or metabolic syndrome. Additionally, we found a significant positive correlation between matriptase levels and metabolic and inflammatory parameters, indicating a potential role for matriptase in the pathogenesis of T2DM and glucose metabolism. Further research on matriptase could lead to its recognition as a novel target for investigation.
OBJECTIVE: Our study aimed to evaluate the correlation between matriptase, a proteolytic enzyme, and metabolic parameters in individuals recently diagnosed with T2DM. We also sought to investigate the potential involvement of matriptase in the development of diabetes.
METHODS: We measured all participants\' metabolic laboratory parameters, including basic biochemical tests, hemograms, high-sensitivity C-reactive protein (hsCRP), and matriptase levels.
RESULTS: Our results showed a significant increase in circulating matriptase levels in individuals with T2DM compared to the control group. Furthermore, individuals with metabolic syndrome had significantly higher matriptase levels than those without in the T2DM and control groups. We also observed that T2DM patients had elevated levels of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), hsCRP, and matriptase, which displayed a positive correlation.
CONCLUSIONS: Our study is the first to report elevated levels of matriptase in individuals with newly diagnosed T2DM and/or metabolic syndrome. Additionally, we found a significant positive correlation between matriptase levels and metabolic and inflammatory parameters, indicating a potential role for matriptase in the pathogenesis of T2DM and glucose metabolism. Further research on matriptase could lead to its recognition as a novel target for investigation.
摘要：
背景：2型糖尿病（T2DM）是一种影响碳水化合物加工的慢性代谢紊乱，蛋白质，和脂质。在T2DM中，代谢失调是通过多种途径发生的,这些途径是由多种脂肪因子和炎性趋化因子水平升高引起的.胰岛素-葡萄糖代谢受损发生在组织中。蛋白水解酶matriptase被认为与葡萄糖代谢密切相关，因为它的糖酵解位点。
目的：我们的研究旨在评估蛋白裂解酶，一种蛋白水解酶，和最近诊断为T2DM的个体的代谢参数。我们还试图研究间质蛋白酶在糖尿病发展中的潜在参与。
方法：我们测量了所有参与者的代谢实验室参数，包括基本的生化测试,血常规,高敏C反应蛋白（hsCRP），和间质蛋白酶水平。
结果：我们的结果显示，与对照组相比，2型糖尿病患者的循环间质蛋白酶水平显著增加。此外，患有代谢综合征的个体的间质蛋白酶水平显著高于2型糖尿病和对照组.我们还观察到T2DM患者的胰岛素抵抗稳态模型评估（HOMA-IR）水平升高，hsCRP,和间质蛋白酶，显示出正相关。
结论：我们的研究首次报道了新诊断的2型糖尿病和/或代谢综合征患者的间质蛋白酶水平升高。此外,我们发现间质蛋白酶水平与代谢和炎症参数之间存在显著正相关，提示蛋白裂解酶在2型糖尿病和糖代谢发病机制中的潜在作用。对间质蛋白酶的进一步研究可能导致其被识别为新的研究靶标。
目的：我们的研究旨在评估蛋白裂解酶，一种蛋白水解酶，和最近诊断为T2DM的个体的代谢参数。我们还试图研究间质蛋白酶在糖尿病发展中的潜在参与。
方法：我们测量了所有参与者的代谢实验室参数，包括基本的生化测试,血常规,高敏C反应蛋白（hsCRP），和间质蛋白酶水平。
结果：我们的结果显示，与对照组相比，2型糖尿病患者的循环间质蛋白酶水平显著增加。此外，患有代谢综合征的个体的间质蛋白酶水平显著高于2型糖尿病和对照组.我们还观察到T2DM患者的胰岛素抵抗稳态模型评估（HOMA-IR）水平升高，hsCRP,和间质蛋白酶，显示出正相关。
结论：我们的研究首次报道了新诊断的2型糖尿病和/或代谢综合征患者的间质蛋白酶水平升高。此外,我们发现间质蛋白酶水平与代谢和炎症参数之间存在显著正相关，提示蛋白裂解酶在2型糖尿病和糖代谢发病机制中的潜在作用。对间质蛋白酶的进一步研究可能导致其被识别为新的研究靶标。
