PDF(Pubmed)
Abstract：
A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primary infection, which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus. Here, we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals (CIs) that were among the first to be infected worldwide and without any possible antigen re-exposure since then. The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs. The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82% and 76%, respectively, over the time period of ten months after infection. Accordingly, the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75% of CIs during the follow-up. Collectively, we provide a comprehensive characterization of the long-term memory T cell response in CIs, suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.
摘要：
2019年冠状病毒病（COVID-19）大流行的一个关键问题是初次感染后针对严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）的特定T细胞反应的持续时间，由于大规模的COVID-19疫苗接种和再次暴露于该病毒，这一问题很难解决。这里,我们对一组恢复期个体(CIs)的长期SARS-CoV-2特异性T细胞应答进行了分析,这些个体是全球首批感染的个体,此后没有任何可能的抗原再暴露.SARS-CoV-2特异性T细胞反应的大小和广度与疾病发作所经过的时间和这些CI的年龄成反比。SARS-CoV-2特异性CD4和CD8T细胞反应的平均幅度降低了约82％和76％，分别,在感染后十个月的时间内。因此，纵向分析还表明,在随访期间,在75%的CI中,SARS-CoV-2特异性T细胞应答显著减弱.总的来说，我们提供了CI中长期记忆T细胞反应的全面表征，提示初次感染后强大的SARS-CoV-2特异性T细胞免疫可能不如先前预期的持久。
