关键词: Atherosclerosis Coronary heart disease Influencing factors Lipid metabolism Preventive treatment

Mesh : Humans Lipid Metabolism Coronary Disease / prevention & control etiology metabolism Obesity Lipoproteins / metabolism

来  源:   DOI:10.1016/j.chemphyslip.2023.105325

Abstract:
The pathogenesis of coronary heart disease is a highly complex process, with lipid metabolism disorders being closely linked to its development. Therefore, this paper analyzes the various factors that influence lipid metabolism, including obesity, genes, intestinal microflora, and ferroptosis, through a comprehensive review of basic and clinical studies. Additionally, this paper delves deeply into the pathways and patterns of coronary heart disease. Based on these findings, it proposes various intervention pathways and therapeutic methods, such as the regulation of lipoprotein enzymes, lipid metabolites, and lipoprotein regulatory factors, as well as the modulation of intestinal microflora and the inhibition of ferroptosis. Ultimately, this paper aims to offer new ideas for the prevention and treatment of coronary heart disease.
摘要:
冠心病的发病机制是一个高度复杂的过程,脂质代谢紊乱与其发展密切相关。因此,本文分析了影响脂质代谢的各种因素,包括肥胖,基因,肠道菌群,和铁性凋亡,通过对基础和临床研究的全面审查。此外,本文深入探讨了冠心病的发病途径和模式。基于这些发现,它提出了各种干预途径和治疗方法,如脂蛋白酶的调节,脂质代谢物,和脂蛋白调节因子,以及肠道菌群的调节和铁凋亡的抑制。最终,本文旨在为冠心病的防治提供新的思路。
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