Abstract：
OBJECTIVE: To investigate the brain functional alterations in dysthyroid optic neuropathy (DON) by evaluating spontaneous neural activity, using functional magnetic resonance imaging (fMRI) with regional homogeneity (ReHo), and its relationship with ophthalmologic performance.
METHODS: Forty-seven patients with thyroid-associated ophthalmopathy (TAO; 20 with DON, 27 with non-DON) and 33 age-, sex-, and education-matched healthy controls (HCs) underwent fMRI. ReHo values were compared using one-way analysis of variance (ANOVA) with post hoc pairwise comparisons (voxel-level p < 0.01, Gaussian random field correction, cluster-level p < 0.05). Correlations between ReHo values and ophthalmological metrics were assessed for DONs, with Bonferroni correction for multiple comparisons (p < 0.004). ROC curves were applied to evaluate the diagnostic performance of ReHo metrics.
RESULTS: ReHo values were significantly lower in the left insula and right superior temporal gyrus, and higher in the left posterior cingulate cortex (LPCC), of DON than of non-DON patients. ReHo values were also significantly lower in the right middle temporal, left insula, and left precentral gyrus in DON than in HCs. Meanwhile, ReHo values were higher in LPCC in non-DON than in HCs. ReHo values correlated with ophthalmic examinations to varying degrees in DON. For distinguishing DON, the ReHo values in LPCC showed optimal individually (AUC = 0.843), the combination of the ReHo in both the left insula and LPCC performed better (AUC = 0.915).
CONCLUSIONS: Spontaneous brain activity differed between TAO with and without DON, which may reflect the underlying pathological mechanism of DON. The ReHo index can be considered a diagnostic biomarker.
CONCLUSIONS: Spontaneous brain activity in DON differed from that in TAO without DON, which may reflect the underlying pathological mechanism of DON. The ReHo index can be considered a diagnostic biomarker for early detection of DON.
CONCLUSIONS: • Dysthyroid optic neuropathy (DON) affects brain activity, which contributes in the understanding of its visual dysfunction. • Regional homogeneity values differ between thyroid-associated ophthalmopathy with and without DON in various brain regions. • Regional homogeneity values can be used as a biomarker in the differential diagnosis of DON.
METHODS: Forty-seven patients with thyroid-associated ophthalmopathy (TAO; 20 with DON, 27 with non-DON) and 33 age-, sex-, and education-matched healthy controls (HCs) underwent fMRI. ReHo values were compared using one-way analysis of variance (ANOVA) with post hoc pairwise comparisons (voxel-level p < 0.01, Gaussian random field correction, cluster-level p < 0.05). Correlations between ReHo values and ophthalmological metrics were assessed for DONs, with Bonferroni correction for multiple comparisons (p < 0.004). ROC curves were applied to evaluate the diagnostic performance of ReHo metrics.
RESULTS: ReHo values were significantly lower in the left insula and right superior temporal gyrus, and higher in the left posterior cingulate cortex (LPCC), of DON than of non-DON patients. ReHo values were also significantly lower in the right middle temporal, left insula, and left precentral gyrus in DON than in HCs. Meanwhile, ReHo values were higher in LPCC in non-DON than in HCs. ReHo values correlated with ophthalmic examinations to varying degrees in DON. For distinguishing DON, the ReHo values in LPCC showed optimal individually (AUC = 0.843), the combination of the ReHo in both the left insula and LPCC performed better (AUC = 0.915).
CONCLUSIONS: Spontaneous brain activity differed between TAO with and without DON, which may reflect the underlying pathological mechanism of DON. The ReHo index can be considered a diagnostic biomarker.
CONCLUSIONS: Spontaneous brain activity in DON differed from that in TAO without DON, which may reflect the underlying pathological mechanism of DON. The ReHo index can be considered a diagnostic biomarker for early detection of DON.
CONCLUSIONS: • Dysthyroid optic neuropathy (DON) affects brain activity, which contributes in the understanding of its visual dysfunction. • Regional homogeneity values differ between thyroid-associated ophthalmopathy with and without DON in various brain regions. • Regional homogeneity values can be used as a biomarker in the differential diagnosis of DON.
摘要：
目的：通过评估自发性神经活动来研究甲状腺功能失调性视神经病变（DON）的脑功能改变，使用具有区域均匀性（ReHo）的功能磁共振成像（fMRI），及其与眼科表现的关系。
方法：47例甲状腺相关眼病患者（TAO；20伴DON，27岁，非DON）和33岁-，sex-,和教育匹配的健康对照（HCs）进行了功能磁共振成像。使用单向方差分析（ANOVA）与事后成对比较（体素水平p<0.01，高斯随机场校正，集群级别p<0.05)。ReHo值与眼科指标之间的相关性被评估为DON，多次比较的Bonferroni校正(p<0.004)。应用ROC曲线评价ReHo指标的诊断性能。
结果：ReHo值在左脑岛和右颞上回明显较低，在左后扣带皮质（LPCC）中更高，DON比非DON患者。ReHo值在右颞叶中部也明显较低，左脑岛,DON比HCs左中央前回。同时,非DON中LPCC的ReHo值高于HC。在DON中，ReHo值与眼科检查有不同程度的相关性。为了区分DON，LPCC中的ReHo值分别显示最佳(AUC=0.843)，左岛和LPCC中ReHo的组合表现更好(AUC=0.915).
结论：有和没有DON的TAO之间的自发性脑活动不同，这可能反映了DON的潜在病理机制。ReHo指数可以被认为是诊断生物标志物。
结论：DON的自发性脑活动不同于没有DON的TAO，这可能反映了DON的潜在病理机制。ReHo指数可以被认为是早期检测DON的诊断性生物标志物。
结论：•甲状腺功能异常视神经病变（DON）影响大脑活动，这有助于理解它的视觉功能障碍。•区域同质性值在不同脑区有和没有DON的甲状腺相关眼病之间不同。•区域均匀性值可用作DON鉴别诊断中的生物标志物。
方法：47例甲状腺相关眼病患者（TAO；20伴DON，27岁，非DON）和33岁-，sex-,和教育匹配的健康对照（HCs）进行了功能磁共振成像。使用单向方差分析（ANOVA）与事后成对比较（体素水平p<0.01，高斯随机场校正，集群级别p<0.05)。ReHo值与眼科指标之间的相关性被评估为DON，多次比较的Bonferroni校正(p<0.004)。应用ROC曲线评价ReHo指标的诊断性能。
结果：ReHo值在左脑岛和右颞上回明显较低，在左后扣带皮质（LPCC）中更高，DON比非DON患者。ReHo值在右颞叶中部也明显较低，左脑岛,DON比HCs左中央前回。同时,非DON中LPCC的ReHo值高于HC。在DON中，ReHo值与眼科检查有不同程度的相关性。为了区分DON，LPCC中的ReHo值分别显示最佳(AUC=0.843)，左岛和LPCC中ReHo的组合表现更好(AUC=0.915).
结论：有和没有DON的TAO之间的自发性脑活动不同，这可能反映了DON的潜在病理机制。ReHo指数可以被认为是诊断生物标志物。
结论：DON的自发性脑活动不同于没有DON的TAO，这可能反映了DON的潜在病理机制。ReHo指数可以被认为是早期检测DON的诊断性生物标志物。
结论：•甲状腺功能异常视神经病变（DON）影响大脑活动，这有助于理解它的视觉功能障碍。•区域同质性值在不同脑区有和没有DON的甲状腺相关眼病之间不同。•区域均匀性值可用作DON鉴别诊断中的生物标志物。
