PDF(Pubmed)
Abstract：
UNASSIGNED: Social interaction is a fundamental human need. Social isolation (SI) can have negative effects on both emotional and cognitive function. However, it is currently unclear how age and the duration of SI affect emotion and recognition function. In addition, there is no specific treatment for the effects of SI.
UNASSIGNED: The adolescence or adult mice were individually housed in cages for 1, 6 or 12 months and for 2 months to estabolish SI mouse model. We investigated the effects of SI on behavior in mice at different ages and under distinct durations of SI, and we explored the possible underlying mechanisms. Then we performed deep brain stimulation (DBS) to evaluate its influences on SI induced behavioral abnormalities.
UNASSIGNED: We found that social recognition was affected in the short term, while social preference was damaged by extremely long periods of SI. In addition to affecting social memory, SI also affects emotion, short-term spatial ability and learning willingness in mice. Myelin was decreased significantly in the medial prefrontal cortex (mPFC) and dorsal hippocampus of socially isolated mice. Cellular activity in response to social stimulation in both areas was impaired by social isolation. By stimulating the mPFC using DBS, we found that DBS alleviated cellular activation disorders in the mPFC after long-term SI and improved social preference in mice.
UNASSIGNED: Our results suggest that the therapeutic potential of stimulating the mPFC with DBS in individuals with social preference deficits caused by long-term social isolation, as well as the effects of DBS on the cellular activity and density of OPCs.
UNASSIGNED: The adolescence or adult mice were individually housed in cages for 1, 6 or 12 months and for 2 months to estabolish SI mouse model. We investigated the effects of SI on behavior in mice at different ages and under distinct durations of SI, and we explored the possible underlying mechanisms. Then we performed deep brain stimulation (DBS) to evaluate its influences on SI induced behavioral abnormalities.
UNASSIGNED: We found that social recognition was affected in the short term, while social preference was damaged by extremely long periods of SI. In addition to affecting social memory, SI also affects emotion, short-term spatial ability and learning willingness in mice. Myelin was decreased significantly in the medial prefrontal cortex (mPFC) and dorsal hippocampus of socially isolated mice. Cellular activity in response to social stimulation in both areas was impaired by social isolation. By stimulating the mPFC using DBS, we found that DBS alleviated cellular activation disorders in the mPFC after long-term SI and improved social preference in mice.
UNASSIGNED: Our results suggest that the therapeutic potential of stimulating the mPFC with DBS in individuals with social preference deficits caused by long-term social isolation, as well as the effects of DBS on the cellular activity and density of OPCs.
摘要：
■社会互动是人类的基本需求。社会隔离（SI）会对情绪和认知功能产生负面影响。然而,目前尚不清楚SI的年龄和持续时间如何影响情绪和识别功能.此外,对于SI的影响没有特定的治疗方法。
■将青春期或成年小鼠分别饲养在笼子中1、6或12个月和2个月以建立SI小鼠模型。我们研究了SI对不同年龄和不同持续时间下小鼠行为的影响。我们探索了可能的潜在机制。然后，我们进行了深部脑刺激（DBS）以评估其对SI引起的行为异常的影响。
■我们发现社会认同在短期内受到影响，而社会偏好被极长时期的SI破坏了。除了影响社会记忆，SI也会影响情绪，小鼠短期空间能力和学习意愿。社会孤立小鼠的内侧前额叶皮层（mPFC）和背侧海马中的髓磷脂显着降低。社会孤立损害了这两个地区响应社会刺激的细胞活动。通过使用DBS刺激mPFC，我们发现DBS缓解了长期SI后mPFC中的细胞活化障碍,并改善了小鼠的社会偏好.
■我们的结果表明，在长期社会孤立导致的社会偏好缺陷的个体中，用DBS刺激mPFC的治疗潜力，以及DBS对OPCs细胞活性和密度的影响。
■将青春期或成年小鼠分别饲养在笼子中1、6或12个月和2个月以建立SI小鼠模型。我们研究了SI对不同年龄和不同持续时间下小鼠行为的影响。我们探索了可能的潜在机制。然后，我们进行了深部脑刺激（DBS）以评估其对SI引起的行为异常的影响。
■我们发现社会认同在短期内受到影响，而社会偏好被极长时期的SI破坏了。除了影响社会记忆，SI也会影响情绪，小鼠短期空间能力和学习意愿。社会孤立小鼠的内侧前额叶皮层（mPFC）和背侧海马中的髓磷脂显着降低。社会孤立损害了这两个地区响应社会刺激的细胞活动。通过使用DBS刺激mPFC，我们发现DBS缓解了长期SI后mPFC中的细胞活化障碍,并改善了小鼠的社会偏好.
■我们的结果表明，在长期社会孤立导致的社会偏好缺陷的个体中，用DBS刺激mPFC的治疗潜力，以及DBS对OPCs细胞活性和密度的影响。
