PDF(Pubmed)
Abstract：
UNASSIGNED: Apoptosis-inducing factor (AIF), a flavin protein in mitochondria, is originally found to induce apoptosis under the stimulation of pro-apoptotic factors. As a mitochondrial flavin adenine dinucleotide-dependent oxidoreductase, AIF is involved in the regulation of mammalian cell metabolism by regulating respiratory enzyme activity, antioxidant stress, promoting mitochondrial autophagy and glucose uptake, etc. Herein, we focused on the research progress regarding the molecular mechanism of AIF in metabolic mediation and the recent research on AIF in metabolic diseases, as well as the AIF-mediated apoptotic process.
UNASSIGNED: Articles for this paper were obtained by reviewing the literature related to the role of AIF in metabolic diseases on PubMed. The search terms included the following: \"apoptosis\", \"metabolism\" or \"metabolic diseases\" plus \"apoptosis-inducing factor\". The titles, abstracts, and full texts of relevant English-language publications published from October 1996 to June 2022 were manually screened to clarify the role of AIF in metabolic diseases.
UNASSIGNED: We found that AIF played an important role in a variety of metabolically-related diseases, such as diabetes, obesity, metabolic syndrome, and tumor metabolism, by mediating apoptosis.
UNASSIGNED: We summarized the important role of AIF in a variety of metabolic diseases, which might help to further expand the understanding of AIF and to develop AIF-related therapeutic targets.
UNASSIGNED: Articles for this paper were obtained by reviewing the literature related to the role of AIF in metabolic diseases on PubMed. The search terms included the following: \"apoptosis\", \"metabolism\" or \"metabolic diseases\" plus \"apoptosis-inducing factor\". The titles, abstracts, and full texts of relevant English-language publications published from October 1996 to June 2022 were manually screened to clarify the role of AIF in metabolic diseases.
UNASSIGNED: We found that AIF played an important role in a variety of metabolically-related diseases, such as diabetes, obesity, metabolic syndrome, and tumor metabolism, by mediating apoptosis.
UNASSIGNED: We summarized the important role of AIF in a variety of metabolic diseases, which might help to further expand the understanding of AIF and to develop AIF-related therapeutic targets.
摘要：
■凋亡诱导因子（AIF），线粒体中的一种黄素蛋白，最初发现在促凋亡因子的刺激下诱导凋亡。作为线粒体黄素腺嘌呤二核苷酸依赖性氧化还原酶，AIF通过调节呼吸酶活性参与哺乳动物细胞代谢的调节，抗氧化应激，促进线粒体自噬和葡萄糖摄取，等。在这里，重点介绍了AIF在代谢介导中的分子机制的研究进展以及AIF在代谢性疾病中的研究进展,以及AIF介导的凋亡过程。
■本文的文章是通过回顾PubMed上有关AIF在代谢疾病中的作用的文献而获得的。搜索词包括：“凋亡”，“代谢”或“代谢疾病”加“凋亡诱导因子”。标题，摘要,我们对1996年10月至2022年6月出版的相关英文出版物的全文进行了手动筛选,以阐明AIF在代谢性疾病中的作用.
■我们发现AIF在多种代谢相关疾病中起着重要作用，比如糖尿病，肥胖，代谢综合征,和肿瘤代谢，通过介导细胞凋亡。
■我们总结了AIF在多种代谢性疾病中的重要作用，这可能有助于进一步扩大对AIF的理解和开发AIF相关的治疗靶点。
■本文的文章是通过回顾PubMed上有关AIF在代谢疾病中的作用的文献而获得的。搜索词包括：“凋亡”，“代谢”或“代谢疾病”加“凋亡诱导因子”。标题，摘要,我们对1996年10月至2022年6月出版的相关英文出版物的全文进行了手动筛选,以阐明AIF在代谢性疾病中的作用.
■我们发现AIF在多种代谢相关疾病中起着重要作用，比如糖尿病，肥胖，代谢综合征,和肿瘤代谢，通过介导细胞凋亡。
■我们总结了AIF在多种代谢性疾病中的重要作用，这可能有助于进一步扩大对AIF的理解和开发AIF相关的治疗靶点。
