PDF(Pubmed)
Abstract：
UNASSIGNED: This study compared dexmedetomidine to fentanyl as an adjunct to ropivacaine for epidural anesthesia in patients undergoing femoral neck fracture surgery.
UNASSIGNED: A total of 56 patients in two different groups with dexmedetomidine and fentanyl underwent the epidural anesthesia method by ropivacaine. This study compared the onset and duration of sensory block, duration of motor block, visual analog scale (VAS) analgesia, and sedation score. The VAS and hemodynamics (e.g., heart rate and mean arterial pressure) were measured every 5 to 15 minutes, then every 15 minutes to the end of the surgery, and then in the 1st, 2nd, 4th, 6th, 12th, and 24th hours after surgery.
UNASSIGNED: In the fentanyl group, the onset time of the sensory block was longer (P < 0.001), and the duration of the block was shorter than in the dexmedetomidine group (P = 0.045). In the fentanyl group, the onset time of motor block was longer than in the dexmedetomidine group (P < 0.001). The mean highest VAS score for each patient in the dexmedetomidine group was 4.9 ± 0.6, compared to the fentanyl group (5.8 ± 0.9), with a significant difference between the two groups (P < 0.001). The sedation score was higher from the 30th minute (P = 0.01) to the 120th minute (P = 0.04) in the patients of the dexmedetomidine group than in the fentanyl group. Side effects, such as dry mouth, hypotension, and bradycardia, were more common in the dexmedetomidine group, and nausea and vomiting were more common in the fentanyl group; however, there were no differences between the groups. There was no respiratory depression in both groups.
UNASSIGNED: This study presented that dexmedetomidine as an adjuvant in epidural anesthesia for orthopedic femoral fracture surgery shortens the onset time of sensory and motor block, increases analgesia length, and prolongs anesthesia. Sedation with dexmedetomidine is better than fentanyl, with fewer side effects, and more effective as preemptive analgesia.
UNASSIGNED: A total of 56 patients in two different groups with dexmedetomidine and fentanyl underwent the epidural anesthesia method by ropivacaine. This study compared the onset and duration of sensory block, duration of motor block, visual analog scale (VAS) analgesia, and sedation score. The VAS and hemodynamics (e.g., heart rate and mean arterial pressure) were measured every 5 to 15 minutes, then every 15 minutes to the end of the surgery, and then in the 1st, 2nd, 4th, 6th, 12th, and 24th hours after surgery.
UNASSIGNED: In the fentanyl group, the onset time of the sensory block was longer (P < 0.001), and the duration of the block was shorter than in the dexmedetomidine group (P = 0.045). In the fentanyl group, the onset time of motor block was longer than in the dexmedetomidine group (P < 0.001). The mean highest VAS score for each patient in the dexmedetomidine group was 4.9 ± 0.6, compared to the fentanyl group (5.8 ± 0.9), with a significant difference between the two groups (P < 0.001). The sedation score was higher from the 30th minute (P = 0.01) to the 120th minute (P = 0.04) in the patients of the dexmedetomidine group than in the fentanyl group. Side effects, such as dry mouth, hypotension, and bradycardia, were more common in the dexmedetomidine group, and nausea and vomiting were more common in the fentanyl group; however, there were no differences between the groups. There was no respiratory depression in both groups.
UNASSIGNED: This study presented that dexmedetomidine as an adjuvant in epidural anesthesia for orthopedic femoral fracture surgery shortens the onset time of sensory and motor block, increases analgesia length, and prolongs anesthesia. Sedation with dexmedetomidine is better than fentanyl, with fewer side effects, and more effective as preemptive analgesia.
摘要：
■本研究比较了右美托咪定与芬太尼作为罗哌卡因辅助用于股骨颈骨折手术患者硬膜外麻醉的效果。
■使用右美托咪定和芬太尼的两组共56例患者接受了罗哌卡因硬膜外麻醉方法。这项研究比较了感觉阻滞的发作和持续时间，电机块的持续时间，视觉模拟量表（VAS）镇痛，和镇静得分。VAS和血液动力学(例如，心率和平均动脉压)每5到15分钟测量一次，手术结束后每15分钟,然后在一号,2nd,第四，6th,12th,手术后24小时.
■在芬太尼组中，感觉阻滞的起效时间较长(P<0.001),阻滞时间短于右美托咪定组(P=0.045).在芬太尼组中，运动阻滞起效时间长于右美托咪定组(P<0.001).右美托咪定组每位患者的平均最高VAS评分为4.9±0.6，与芬太尼组相比为5.8±0.9，两组间有显著性差异(P<0.001)。右美托咪定组患者第30分钟(P=0.01)至第120分钟(P=0.04)的镇静评分高于芬太尼组。副作用,比如口干,低血压,和心动过缓,在右美托咪定组中更常见，恶心和呕吐在芬太尼组中更为常见；然而，两组间无差异.两组均无呼吸抑制。
■本研究表明，右美托咪定作为硬膜外麻醉辅助应用于股骨骨折矫形手术可缩短感觉和运动阻滞的起效时间，增加镇痛时间，延长麻醉时间。右美托咪定镇静效果优于芬太尼，副作用少，作为超前镇痛更有效。
■使用右美托咪定和芬太尼的两组共56例患者接受了罗哌卡因硬膜外麻醉方法。这项研究比较了感觉阻滞的发作和持续时间，电机块的持续时间，视觉模拟量表（VAS）镇痛，和镇静得分。VAS和血液动力学(例如，心率和平均动脉压)每5到15分钟测量一次，手术结束后每15分钟,然后在一号,2nd,第四，6th,12th,手术后24小时.
■在芬太尼组中，感觉阻滞的起效时间较长(P<0.001),阻滞时间短于右美托咪定组(P=0.045).在芬太尼组中，运动阻滞起效时间长于右美托咪定组(P<0.001).右美托咪定组每位患者的平均最高VAS评分为4.9±0.6，与芬太尼组相比为5.8±0.9，两组间有显著性差异(P<0.001)。右美托咪定组患者第30分钟(P=0.01)至第120分钟(P=0.04)的镇静评分高于芬太尼组。副作用,比如口干,低血压,和心动过缓,在右美托咪定组中更常见，恶心和呕吐在芬太尼组中更为常见；然而，两组间无差异.两组均无呼吸抑制。
■本研究表明，右美托咪定作为硬膜外麻醉辅助应用于股骨骨折矫形手术可缩短感觉和运动阻滞的起效时间，增加镇痛时间，延长麻醉时间。右美托咪定镇静效果优于芬太尼，副作用少，作为超前镇痛更有效。
