Abstract：
Treatment of gastrointestinal pain remains a significant challenge in the management of many disorders of gut-brain interaction (DGBI). Pharmacologic agents and various behavioral therapies are among the potential therapeutic options for pain-predominant DGBI such as irritable bowel syndrome, functional dyspepsia, functional heartburn, and centrally mediated abdominal pain syndrome. In the retrospective study published in this journal, Luo et al. examine the use of prescription pain medications from a global perspective among patients with DGBI using the Rome Foundation Global Epidemiology Study. This review article provides an overview of usage patterns of various pharmacologic pain management agents (opioids, central neuromodulators, antispasmodics, and other peripherally acting agents) and non-pharmacologic therapies in the context of clinical practice recommendations on the management of DGBI pain.
摘要：
胃肠道疼痛的治疗在许多肠-脑相互作用(DGBI)障碍的管理中仍然是重大挑战。药物和各种行为疗法是疼痛为主的DGBI如肠易激综合征的潜在治疗选择。功能性消化不良,功能性胃灼热,和中枢介导的腹痛综合征。在这篇杂志上发表的回顾性研究中，Luoetal.使用罗马基金会全球流行病学研究，从全球角度检查DGBI患者中处方止痛药的使用情况。这篇综述文章概述了各种药物疼痛管理药物的使用模式(阿片类药物，中枢神经调质，抗痉挛药,和其他外周作用剂）和非药物疗法在DGBI疼痛管理的临床实践建议中。
