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Abstract：
BACKGROUND: To investigate the characteristics of reticular fibre structure (RFS) in parathyroid adenoma (PTA), atypical parathyroid tumour (APT), and parathyroid carcinoma (PTC), and to assess its value as a diagnostic indicator.
METHODS: Clinical data and pathological specimens of patients with PTA, APT or PTC were collected. Reticular fibre staining was performed to observe the characteristics of RFS. This study evaluated the incidence of RFS destruction in parathyroid tumours, compared RFS destruction between primary PTC and recurrent and metastatic PTC, and explored the association between RFS destruction and clinicopathological features of APT and primary PTC.
RESULTS: Reticular fibre staining was performed in 50 patients with PTA, 25 patients with APT, and 36 patients with PTC. In PTA cases, a delicate RFS was observed. In both the APT and PTC groups, incomplete RFS areas were observed. The incidence of RFS destruction was different among the PTA, APT, and PTC groups (P < 0.001, χ2-test), at 0% (0/50), 44% (11/25), and 86% (31/36), respectively. When differentiating PTC from APT, the sensitivity and specificity of RFS destruction were 81% and 56%, respectively. The incidence of RFS destruction was 73% (8/11) in the primary PTC group and 92% (23/25) in the recurrent and metastatic PTC groups. In both the APT group and primary PTC group, no correlation was found between RFS destruction and clinicopathological features.
CONCLUSIONS: RFS destruction may indicate that parathyroid tumours have unfavourable biological behaviours.Reticular fibre staining may be a valuable tool for improving the diagnostic accuracy in parathyroid tumours.
METHODS: Clinical data and pathological specimens of patients with PTA, APT or PTC were collected. Reticular fibre staining was performed to observe the characteristics of RFS. This study evaluated the incidence of RFS destruction in parathyroid tumours, compared RFS destruction between primary PTC and recurrent and metastatic PTC, and explored the association between RFS destruction and clinicopathological features of APT and primary PTC.
RESULTS: Reticular fibre staining was performed in 50 patients with PTA, 25 patients with APT, and 36 patients with PTC. In PTA cases, a delicate RFS was observed. In both the APT and PTC groups, incomplete RFS areas were observed. The incidence of RFS destruction was different among the PTA, APT, and PTC groups (P < 0.001, χ2-test), at 0% (0/50), 44% (11/25), and 86% (31/36), respectively. When differentiating PTC from APT, the sensitivity and specificity of RFS destruction were 81% and 56%, respectively. The incidence of RFS destruction was 73% (8/11) in the primary PTC group and 92% (23/25) in the recurrent and metastatic PTC groups. In both the APT group and primary PTC group, no correlation was found between RFS destruction and clinicopathological features.
CONCLUSIONS: RFS destruction may indicate that parathyroid tumours have unfavourable biological behaviours.Reticular fibre staining may be a valuable tool for improving the diagnostic accuracy in parathyroid tumours.
摘要：
背景：为了研究甲状旁腺腺瘤（PTA）的网状纤维结构（RFS）的特征，非典型甲状旁腺肿瘤（APT），和甲状旁腺癌（PTC），并评估其作为诊断指标的价值。
方法：PTA患者的临床资料和病理标本，收集APT或PTC。进行网状纤维染色以观察RFS的特性。这项研究评估了甲状旁腺肿瘤中RFS破坏的发生率，比较原发性PTC与复发性和转移性PTC之间的RFS破坏，并探讨了RFS破坏与APT和原发性PTC临床病理特征之间的关系。
结果：50例PTA患者行网状纤维染色，25例APT患者，和36例PTC患者。在PTA案例中，观察到微妙的RFS。在APT和PTC组中，观察到不完全RFS区域。RFS破坏的发生率在PTA之间是不同的，APT,和PTC组(P<0.001，χ2检验)，0%(0/50)，44%（11/25），和86%（31/36），分别。区分PTC和APT时，RFS破坏的敏感性和特异性分别为81%和56%,分别。原发性PTC组RFS破坏的发生率为73％（8/11），复发和转移性PTC组为92％（23/25）。在APT组和主要PTC组中，RFS破坏与临床病理特征无相关性.
结论：RFS破坏可能表明甲状旁腺肿瘤具有不利的生物学行为。网状纤维染色可能是提高甲状旁腺肿瘤诊断准确性的有价值的工具。
方法：PTA患者的临床资料和病理标本，收集APT或PTC。进行网状纤维染色以观察RFS的特性。这项研究评估了甲状旁腺肿瘤中RFS破坏的发生率，比较原发性PTC与复发性和转移性PTC之间的RFS破坏，并探讨了RFS破坏与APT和原发性PTC临床病理特征之间的关系。
结果：50例PTA患者行网状纤维染色，25例APT患者，和36例PTC患者。在PTA案例中，观察到微妙的RFS。在APT和PTC组中，观察到不完全RFS区域。RFS破坏的发生率在PTA之间是不同的，APT,和PTC组(P<0.001，χ2检验)，0%(0/50)，44%（11/25），和86%（31/36），分别。区分PTC和APT时，RFS破坏的敏感性和特异性分别为81%和56%,分别。原发性PTC组RFS破坏的发生率为73％（8/11），复发和转移性PTC组为92％（23/25）。在APT组和主要PTC组中，RFS破坏与临床病理特征无相关性.
结论：RFS破坏可能表明甲状旁腺肿瘤具有不利的生物学行为。网状纤维染色可能是提高甲状旁腺肿瘤诊断准确性的有价值的工具。
