PDF(Pubmed)
Abstract：
Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial component of the scavenger receptor family and is vital in protecting mammals from infectious diseases. Although research on SCARF2 is limited, mutations in this protein have been shown to cause skeletal abnormalities in both SCARF2-deficient mice and individuals with Van den Ende-Gupta syndrome (VDEGS), which is also associated with SCARF2 mutations. In contrast, other scavenger receptors have demonstrated versatile responses and have been found to aid in pathogen elimination, lipid transportation, intracellular cargo transportation, and work in tandem with various coreceptors. This review will concentrate on recent progress in comprehending SCARF2 and the functions played by members of the Scavenger Receptor Family in pre-diagnostic diseases.
摘要：
清除剂受体F类成员2（SCARF2），也称为F型清道夫受体家族基因，编码由内皮细胞2表达的清道夫受体(SREC-II)。这种蛋白质是清道夫受体家族的重要组成部分，在保护哺乳动物免受传染病的侵害方面至关重要。虽然对SCARF2的研究有限，该蛋白质的突变已被证明会导致SCARF2缺陷小鼠和VandenEnde-Gupta综合征（VDEGS）个体的骨骼异常，这也与SCARF2突变有关。相比之下,其他清道夫受体已显示出多种反应，并已被发现有助于消除病原体，脂质运输，细胞内货物运输，并与各种共受体协同工作。这篇综述将集中在理解SCARF2以及清道夫受体家族成员在诊断前疾病中的功能方面的最新进展。
