PDF(Pubmed)
Abstract：
The Programmed death-1 (PD-1) and its programmed death-ligand 1 (PD-L1) comprise the PD-1/PD-L1 axis and maintain tumor immune evasion. Cancer immunotherapy based on anti-PD-1/PD-L1 antibodies is the most promising anti-tumor treatment available but is currently facing the thorny problem of unsatisfactory outcomes. Traditional Chinese Medicine (TCM), with its rich heritage of Chinese medicine monomers, herbal formulas, and physical therapies like acupuncture, moxibustion, and catgut implantation, is a multi-component and multi-target system of medicine known for enhancing immunity and preventing the spread of disease. TCM is often used as an adjuvant therapy for cancer in clinical practices, and recent studies have demonstrated the synergistic effects of combining TCM with cancer immunotherapy. In this review, we examined the PD-1/PD-L1 axis and its role in tumor immune escape while exploring how TCM therapies can modulate the PD-1/PD-L1 axis to improve the efficacy of cancer immunotherapy. Our findings suggest that TCM therapy can enhance cancer immunotherapy by reducing the expression of PD-1 and PD-L1, regulating T-cell function, improving the tumor immune microenvironment, and regulating intestinal flora. We hope this review may serve as a valuable resource for future studies on the sensitization of immune checkpoint inhibitors (ICIs) therapy.
摘要：
程序性死亡-1(PD-1)及其程序性死亡配体1(PD-L1)包含PD-1/PD-L1轴并维持肿瘤免疫逃避。基于抗PD-1/PD-L1抗体的癌症免疫疗法是最有前途的抗肿瘤治疗方法，但目前面临着结果不令人满意的棘手问题。中医(TCM),凭借其丰富的中药单体遗产，草药配方，以及针灸等物理疗法，艾灸,和肠线植入，是一种多组分和多目标的药物系统，以增强免疫力和防止疾病传播而闻名。中医在临床实践中经常被用作癌症的辅助治疗,最近的研究已经证明了中药与癌症免疫治疗的协同作用。在这次审查中,我们研究了PD-1/PD-L1轴及其在肿瘤免疫逃逸中的作用,同时探讨了中医药疗法如何调节PD-1/PD-L1轴以提高癌症免疫治疗的疗效.我们的发现表明，中医治疗可以通过降低PD-1和PD-L1的表达，调节T细胞功能来增强癌症的免疫治疗。改善肿瘤免疫微环境，和调节肠道菌群。我们希望这篇综述可以作为未来研究免疫检查点抑制剂（ICIs）治疗敏化的宝贵资源。
