PDF(Pubmed)
Abstract：
Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and is characterized by organ failure and high short-term mortality. Heterogeneous definitions and diagnostic criteria for the clinical condition have been proposed in different geographic regions due to the differences in aetiologies and precipitating events. Several predictive and prognostic scores have been developed and validated to guide clinical management. The specific pathophysiology of ACLF remains uncertain and is mainly associated with an intense systemic inflammatory response and immune-metabolism disorder based on current evidence. For ACLF patients, standardization of the treatment paradigm is required for different disease stages that may provide targeted treatment strategies for individual needs.
摘要：
慢性急性肝衰竭（ACLF）已被认为是基于慢性肝病的急性恶化的严重临床综合征，其特征是器官衰竭和高短期死亡率。由于病因和诱发事件的差异，在不同的地理区域提出了临床状况的不同定义和诊断标准。已经开发并验证了几种预测和预后评分以指导临床管理。ACLF的具体病理生理学仍不确定，主要与强烈的全身炎症反应和免疫代谢紊乱有关。对于ACLF患者，对于不同的疾病阶段，需要标准化的治疗模式，可以为个人需求提供有针对性的治疗策略。
