Abstract：
In the body, nerve tissue is not only present in the central nervous system, but also in the periphery. The enteric nervous system (ENS) is a highly organized intrinsic network of neurons and glial cells grouped to form interconnected ganglia. Glial cells in the ENS are a fascinating cell population: their neurotrophic role is well established, as well as their plasticity in specific circumstances. Gene expression profiling studies indicate that ENS glia retain neurogenic potential. The identification of neurogenic glial subtype(s) and the molecular basis of glia-derived neurogenesis may have profound biological and clinical implications. In this review, we discuss the potential of using gene-editing for ENS glia and cell transplantation as therapies for enteric neuropathies. Glia in the ENS: target or tool for nerve tissue repair?
摘要：
在身体里,神经组织不仅存在于中枢神经系统中，但也在外围。肠神经系统（ENS）是神经元和神经胶质细胞的高度组织化的内在网络，它们被分组以形成相互连接的神经节。ENS中的神经胶质细胞是一个令人着迷的细胞群：它们的神经营养作用已经确立，以及它们在特定情况下的可塑性。基因表达谱分析研究表明ENS神经胶质保留了神经源性潜能。神经源性神经胶质亚型的鉴定和神经胶质源性神经发生的分子基础可能具有深远的生物学和临床意义。在这次审查中,我们讨论了将基因编辑用于ENS神经胶质细胞和细胞移植作为肠神经病治疗的潜力.ENS中的胶质细胞：神经组织修复的目标或工具？
