Abstract：
Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the development of S. aureus studies. However, due to the substantial differences in immune system between mice and humans, the conventional mouse studies are not predictive of success in humans, in which case humanized mice may overcome this limitation to some extent. Humanized mice can be used to study the human-specific virulence factors produced by S. aureus and the mechanisms by which S. aureus interacts with humans. This review outlined the latest advances in humanized mouse models used in S. aureus studies.
摘要：
金黄色葡萄球菌（SA）是人类的重要病原体，可引起广泛的疾病，轻度皮肤感染，严重的骨髓炎到致命的肺炎，败血症和败血症。小鼠模型极大地促进了SA研究的发展。然而,由于小鼠和人类之间免疫系统的巨大差异，传统的小鼠研究不能预测人类的成功，在这种情况下,人源化小鼠(HM)可以在一定程度上克服这种限制。HM可用于研究由SA产生的人特异性毒力因子以及SA与人相互作用的机制。这篇综述概述了SA研究中使用的HM模型的最新进展。
