Abstract：
Zenker per-oral endoscopic myotomy (ZPOEM) has become a promising technique for Zenker\'s diverticulum (ZD). The aim of this study was to add to the limited body of literature evaluating the safety and efficacy of ZPOEM. A prospectively maintained database was retrospectively reviewed to identify patients who underwent ZPOEM at two separate institutions between January 2020 and January 2022. Demographics, preoperative and postoperative clinical data, intraoperative data, adverse events, and length of stay were analyzed. A total of 40 patients (mean age 72.5 years, 62.5% male) were included. Average operative time was 54.7 minutes and average length of stay was 1.1 days. There were three adverse events, and only one was related to the technical aspects of the procedure. Patients showed improvement in the Functional Oral Intake Scale (FOIS) scores at 1 month (5 vs 7, p < 0.0001). The median FOIS scores remained 7 at both 6 and 12 months, although this improvement was not statistically significant at these time intervals (p = 0.46 and 0.37, respectively). Median dysphagia scores were decreased at 1 (2.5 vs 0, p < 0.0001), 6 (2.5 vs 0, p < 0.0001), and 12 months (2.5 vs 0, p = 0.016). The number of patients reporting ≥1 symptom was also decreased at 1 (40 vs 9, p < 0.0001) and 6 months (40 vs 1, p = 0.041). Although the number of patients reporting ≥1 symptom remained consistent at 12 months, this was not statistically significant (40 vs 1, p = 0.13). ZPOEM is a safe and highly effective treatment for the management of ZD. .
摘要：
Zenker经口内镜肌切开术（ZPOEM）已成为Zenker憩室（ZD）的一种有前途的技术。这项研究的目的是增加对ZPOEM的安全性和有效性进行评估的有限文献。对前瞻性维护的数据库进行回顾性审查，以确定在2020年1月至2022年1月期间在两个独立机构接受ZPOEM的患者。人口统计,术前、术后临床资料,术中数据,不良事件,分析了住院时间。共有40名患者（平均年龄72.5岁，包括62.5%男性）。平均手术时间为54.7分钟，平均住院时间为1.1天。有三个不良事件，只有一个与程序的技术方面有关。患者在1个月时的功能性口服摄入量表（FOIS）评分有所改善（5vs7，p<0.0001）。在6个月和12个月时，FOIS的中位数仍然是7分，尽管这种改善在这些时间间隔没有统计学意义(分别为p=0.46和0.37).吞咽困难评分中位数在1时降低（2.5vs0，p<0.0001），6（2.5vs0，p<0.0001），和12个月（2.5vs0，p=0.016）。报告≥1症状的患者数量在1个月（40vs9，p<0.0001）和6个月（40vs1，p=0.041）时也减少。尽管报告≥1症状的患者数量在12个月时保持一致，这没有统计学意义(40vs1,p=0.13).ZPOEM是一种安全有效的ZD治疗方法。.
