Abstract：
OBJECTIVE: This narrative review aims to investigate the effects of drugs on implant osseointegration, analyzing their potential positive or negative impact on the direct structural and functional connection between bone and load-carrying implants.
BACKGROUND: The review seeks to provide a comprehensive understanding of osseointegration, which refers to the successful integration of an implant with living bone, resulting in no progressive relative movement between them. Exploring the effects of drugs on implant osseointegration is crucial for optimizing outcomes and enhancing patient care in orthopedic implant procedures.
METHODS: Relevant studies on the effects of drugs on implant osseointegration were identified through a literature search. Electronic databases, including PubMed, Embase, and Google Scholar, were utilized, employing appropriate keywords and MeSH terms related to osseointegration, implants, and drug interventions. The search was limited to English studies.
CONCLUSIONS: This overview presents a detailed analysis of the effects of drugs on implant osseointegration. It explores drugs such as bisphosphonates, teriparatide, statins, angiotensin-converting enzyme inhibitors, beta-blockers, nitrites, and thiazide diuretics as promoters of osseointegration. Conversely, loop diuretics, non-steroidal anti-inflammatory drugs, corticosteroids, cyclosporine A, cisplatin, methotrexate, antibiotics, proton pump inhibitors (PPIs), antiepileptics, selective serotonin reuptake inhibitors (SSRIs), and anticoagulants are discussed as inhibitors of the process. The role of vitamin D3 remains uncertain. The complex relationship between drugs and the biology of implant osseointegration is emphasized, underscoring the need for further in vitro and in vivo studies to validate their effects CONCLUSION: This narrative review contributes to the literature by providing an overview of the effects of drugs on implant osseointegration. It highlights the complexity of the subject and emphasizes the necessity for more extensive and sophisticated studies in the future. Based on the synthesis of the reviewed literature, certain drugs, such as bisphosphonates and teriparatide, show potential for promoting implant osseointegration, while others, including loop diuretics and certain antibiotics, may impede the process. However, additional research is required to solidify these conclusions and effectively inform clinical practice.
BACKGROUND: The review seeks to provide a comprehensive understanding of osseointegration, which refers to the successful integration of an implant with living bone, resulting in no progressive relative movement between them. Exploring the effects of drugs on implant osseointegration is crucial for optimizing outcomes and enhancing patient care in orthopedic implant procedures.
METHODS: Relevant studies on the effects of drugs on implant osseointegration were identified through a literature search. Electronic databases, including PubMed, Embase, and Google Scholar, were utilized, employing appropriate keywords and MeSH terms related to osseointegration, implants, and drug interventions. The search was limited to English studies.
CONCLUSIONS: This overview presents a detailed analysis of the effects of drugs on implant osseointegration. It explores drugs such as bisphosphonates, teriparatide, statins, angiotensin-converting enzyme inhibitors, beta-blockers, nitrites, and thiazide diuretics as promoters of osseointegration. Conversely, loop diuretics, non-steroidal anti-inflammatory drugs, corticosteroids, cyclosporine A, cisplatin, methotrexate, antibiotics, proton pump inhibitors (PPIs), antiepileptics, selective serotonin reuptake inhibitors (SSRIs), and anticoagulants are discussed as inhibitors of the process. The role of vitamin D3 remains uncertain. The complex relationship between drugs and the biology of implant osseointegration is emphasized, underscoring the need for further in vitro and in vivo studies to validate their effects CONCLUSION: This narrative review contributes to the literature by providing an overview of the effects of drugs on implant osseointegration. It highlights the complexity of the subject and emphasizes the necessity for more extensive and sophisticated studies in the future. Based on the synthesis of the reviewed literature, certain drugs, such as bisphosphonates and teriparatide, show potential for promoting implant osseointegration, while others, including loop diuretics and certain antibiotics, may impede the process. However, additional research is required to solidify these conclusions and effectively inform clinical practice.
摘要：
目的：这篇叙述性综述旨在研究药物对植入物骨整合的影响，分析它们对骨骼和承载植入物之间的直接结构和功能连接的潜在正面或负面影响。
背景：该综述旨在提供对骨整合的全面了解，指的是植入物与活骨的成功整合，导致它们之间没有渐进的相对运动。探索药物对植入物骨整合的影响对于优化结果和增强骨科植入物手术中的患者护理至关重要。
方法：通过文献检索确定了药物对种植体骨整合影响的相关研究。电子数据库,包括PubMed,Embase,和谷歌学者，被利用，采用与骨整合相关的适当关键字和MeSH术语，植入物,和药物干预。搜索仅限于英语研究。
结论：本综述详细分析了药物对植入物骨整合的影响。它探索了双膦酸盐等药物，特立帕肽,他汀类药物，血管紧张素转换酶抑制剂，β受体阻滞剂，亚硝酸盐，和噻嗪类利尿剂作为骨整合的促进剂。相反，loop利尿剂，非甾体抗炎药，皮质类固醇,环孢菌素A,顺铂,甲氨蝶呤,抗生素,质子泵抑制剂（PPI），抗癫痫药,选择性5-羟色胺再摄取抑制剂（SSRIs），和抗凝剂被讨论为该过程的抑制剂。维生素D3的作用仍然不确定。强调了药物与种植体骨整合生物学之间的复杂关系，强调需要进一步的体外和体内研究来验证其效果。结论：这篇叙述性综述通过概述药物对植入物骨整合的影响，为文献做出了贡献。它强调了主题的复杂性，并强调了未来进行更广泛和复杂研究的必要性。在综述文献的基础上，某些药物,如二膦酸盐和特立帕肽，显示促进植入物骨整合的潜力，而其他人,包括环状利尿剂和某些抗生素，可能会阻碍这一进程。然而,需要额外的研究来巩固这些结论并有效地指导临床实践。
背景：该综述旨在提供对骨整合的全面了解，指的是植入物与活骨的成功整合，导致它们之间没有渐进的相对运动。探索药物对植入物骨整合的影响对于优化结果和增强骨科植入物手术中的患者护理至关重要。
方法：通过文献检索确定了药物对种植体骨整合影响的相关研究。电子数据库,包括PubMed,Embase,和谷歌学者，被利用，采用与骨整合相关的适当关键字和MeSH术语，植入物,和药物干预。搜索仅限于英语研究。
结论：本综述详细分析了药物对植入物骨整合的影响。它探索了双膦酸盐等药物，特立帕肽,他汀类药物，血管紧张素转换酶抑制剂，β受体阻滞剂，亚硝酸盐，和噻嗪类利尿剂作为骨整合的促进剂。相反，loop利尿剂，非甾体抗炎药，皮质类固醇,环孢菌素A,顺铂,甲氨蝶呤,抗生素,质子泵抑制剂（PPI），抗癫痫药,选择性5-羟色胺再摄取抑制剂（SSRIs），和抗凝剂被讨论为该过程的抑制剂。维生素D3的作用仍然不确定。强调了药物与种植体骨整合生物学之间的复杂关系，强调需要进一步的体外和体内研究来验证其效果。结论：这篇叙述性综述通过概述药物对植入物骨整合的影响，为文献做出了贡献。它强调了主题的复杂性，并强调了未来进行更广泛和复杂研究的必要性。在综述文献的基础上，某些药物,如二膦酸盐和特立帕肽，显示促进植入物骨整合的潜力，而其他人,包括环状利尿剂和某些抗生素，可能会阻碍这一进程。然而,需要额外的研究来巩固这些结论并有效地指导临床实践。
