PDF(Pubmed)
Abstract：
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage damage and synovial inflammation and carries an enormous public health and economic burden. It is crucial to uncover the potential mechanisms of OA pathogenesis to develop new targets for OA treatment. In recent years, the pathogenic role of the gut microbiota in OA has been well recognized. Gut microbiota dysbiosis can break host-gut microbe equilibrium, trigger host immune responses and activate the \"gut-joint axis\", which aggravates OA. However, although the role of the gut microbiota in OA is well known, the mechanisms modulating the interactions between the gut microbiota and host immunity remain unclear. This review summarizes research on the gut microbiota and the involved immune cells in OA and interprets the potential mechanisms for the interactions between the gut microbiota and host immune responses from four aspects: gut barrier, innate immunity, adaptive immunity and gut microbiota modulation. Future research should focus on the specific pathogen or the specific changes in the gut microbiota composition to identify the related signaling pathways involved in the pathogenesis of OA. In addition, future studies should include more novel interventions on immune cell modifications and gene regulation of specific gut microbiota related to OA to validate the application of gut microbiota modulation in the onset of OA.
摘要：
骨关节炎（OA）是一种以软骨损伤和滑膜炎为特征的慢性退行性关节疾病，具有巨大的公共卫生和经济负担。揭示OA发病的潜在机制对于开发OA治疗的新靶点至关重要。近年来,肠道菌群在OA中的致病作用已得到广泛认可。肠道微生物菌群失调可以打破宿主-肠道微生物平衡，触发宿主免疫反应并激活“肠关节轴”，这加剧了OA。然而,尽管肠道菌群在OA中的作用是众所周知的，调节肠道菌群与宿主免疫之间相互作用的机制尚不清楚。本文综述了肠道菌群及其参与OA的免疫细胞的研究进展,并从肠道屏障、先天免疫,适应性免疫和肠道菌群调节。未来的研究应集中于特定的病原体或肠道菌群组成的特定变化，以确定参与OA发病的相关信号通路。此外,未来的研究应包括对免疫细胞修饰和与OA相关的特定肠道菌群的基因调控的更多新干预措施,以验证肠道菌群调节在OA发病中的应用.
