PDF(Pubmed)
Abstract：
Misoprostol, a synthetic prostaglandin E1 analog, is currently used for medical termination of pregnancy. In the summary of the product characteristics of different market authorization holders of misoprostol tablets, approved by major regulators, serious mucocutaneous reactions, including toxic epidermal necrolysis are not documented as adverse effects. We are now reporting an unusual case of toxic epidermal necrolysis following the use of misoprostol 200 mcg tablets prescribed for termination of a pregnancy. A 25-year-old grand multipara woman from the Gash-Barka region of Eritrea visited Tesseney hospital with a history of amenorrhea that lasted for four months. She was admitted as a case of missed abortion for medical termination of pregnancy. Following three doses of misoprostol 200 mcg tablet the patient developed toxic epidermal necrolysis. Except misoprostol, no other possible alternatives that could explain the condition were identified. Accordingly, the adverse effect was judged to be possibly related to misoprostol. The patient recovered after four weeks of treatment without sequelae. Toxic epidermal necrolysis could, therefore, be a possible adverse effect of misoprostol that needs to be further investigated with better epidemiological studies.
摘要：
米索前列醇,合成前列腺素E1类似物,目前用于医疗终止妊娠。在总结米索前列醇片不同市场授权持有人的产品特点时，由主要监管机构批准，严重的皮肤粘膜反应,包括中毒性表皮坏死松解症没有记录为不良反应。我们现在报告了使用米索前列醇200mcg片剂终止妊娠后，中毒性表皮坏死松解症的不寻常病例。来自厄立特里亚Gash-Barka地区的一名25岁的成年妇女访问了Tesseney医院，并有持续四个月的闭经史。她因医疗终止妊娠而因错过流产而入院。在三个剂量的米索前列醇200mcg片剂后，患者出现了毒性表皮坏死松解症。除了米索前列醇,没有确定其他可能的替代方案可以解释这种情况。因此，不良反应被认为可能与米索前列醇有关.患者治疗4周后痊愈，无后遗症。中毒性表皮坏死松解症，因此,可能是米索前列醇的不良反应，需要通过更好的流行病学研究进一步研究。
