Abstract：
The aim of the study was to determine the association between platelet indices and obesity in children. A total of 190 overweight or obese children (mean age: 13.29 ± 2.54, M/F: 0.74) and 100 normal-weight children (mean age: 12.72 ± 2.23, M/F:1.04) were enrolled in the study. Platelet count (PLT), platelet indices, and ratios were determined. No significant difference was observed in terms of mean platelet volume (MPV) and platelet distribution width (PDW) levels and MPV/plateletcrit (PCT) and PDW/PCT ratios between overweight, obese, and normal-weight groups, whereas significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT ratios between each group. PLT and PCT levels were significantly higher in the obese group than in the overweight and normal-weight groups (P = 0.003, P = 0.002, respectively). Children with obesity had lower MPV/PLT and PDW/PLT ratios than the other groups (P = 0.001, P = 0.02, respectively). Overweight and obese children with insulin resistance (IR) had higher PLT and lower MPV/PLT, and PDW/PLT ratios than the children without IR (P = 0.034, P = 0.04, P = 0.013, respectively).
CONCLUSIONS: Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children.
BACKGROUND: • Obesity is associated with a chronic low-grade systemic inflammation. • Platelets play a crucial role in coagulation, hemostasis, thrombosis, immunomodulatory processes, inflammation, and atherothrombosis.
BACKGROUND: • Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children. • Overweight and obese children with insulin resistance had higher PLT and lower MPV/PLT and PDW/PLT ratios than the children without insülin resistance.
CONCLUSIONS: Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children.
BACKGROUND: • Obesity is associated with a chronic low-grade systemic inflammation. • Platelets play a crucial role in coagulation, hemostasis, thrombosis, immunomodulatory processes, inflammation, and atherothrombosis.
BACKGROUND: • Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children. • Overweight and obese children with insulin resistance had higher PLT and lower MPV/PLT and PDW/PLT ratios than the children without insülin resistance.
摘要：
该研究的目的是确定血小板指数与儿童肥胖之间的关系。共纳入190名超重或肥胖儿童（平均年龄：13.29±2.54，M/F：0.74）和100名正常体重儿童（平均年龄：12.72±2.23，M/F：1.04）。血小板计数(PLT),血小板指数,并确定了比率。在平均血小板体积（MPV）和血小板分布宽度（PDW）水平以及超重之间的MPV/plateletcrit（PCT）和PDW/PCT比率方面没有观察到显着差异，肥胖，和正常体重组，而在PLT方面观察到显著差异，PCT,MPV/PLT,各组间PDW/PLT比值。肥胖组的PLT和PCT水平明显高于超重和正常体重组（分别为P=0.003，P=0.002）。肥胖儿童的MPV/PLT和PDW/PLT比率低于其他组（分别为P=0.001，P=0.02）。超重和肥胖儿童胰岛素抵抗（IR）的PLT较高，MPV/PLT较低，PDW/PLT比值高于无IR患儿(分别为P=0.034,P=0.04,P=0.013)。
结论：在PLT方面观察到显着差异，PCT,MPV/PLT,和PDW/PLT之间的超重，肥胖，和体重正常的孩子。
背景：•肥胖与慢性低度全身性炎症相关。•血小板在凝血中起关键作用，止血,血栓形成,免疫调节过程，炎症,和动脉粥样硬化血栓形成。
背景：•在PLT方面观察到显着差异，PCT,MPV/PLT,和PDW/PLT之间的超重，肥胖，和体重正常的孩子。•与没有胰岛素抵抗的儿童相比，超重和肥胖的胰岛素抵抗儿童的PLT更高，MPV/PLT和PDW/PLT比率更低。
结论：在PLT方面观察到显着差异，PCT,MPV/PLT,和PDW/PLT之间的超重，肥胖，和体重正常的孩子。
背景：•肥胖与慢性低度全身性炎症相关。•血小板在凝血中起关键作用，止血,血栓形成,免疫调节过程，炎症,和动脉粥样硬化血栓形成。
背景：•在PLT方面观察到显着差异，PCT,MPV/PLT,和PDW/PLT之间的超重，肥胖，和体重正常的孩子。•与没有胰岛素抵抗的儿童相比，超重和肥胖的胰岛素抵抗儿童的PLT更高，MPV/PLT和PDW/PLT比率更低。
