PDF(Pubmed)
Abstract：
UNASSIGNED: It has been reported that some herbal products affect reproduction. To date, reproductive toxicity of Syzygium guineense has not been investigated although the plant is widely used in treating fertility related problems. Thus, the objective of the current study was to investigate the toxic effects of 70% ethanol extract of S. guineense leaves on the reproductive function and histopathology of reproductive organs in female rats.
UNASSIGNED: Eighty female Wistar albino rats were randomly divided into four groups where each group consisted of 20 rats. Rats in the first three groups were treated with S. guineense extract at doses of 250, 500 and 1000 mg/kg body weight, respectively. The fourth group served as a control group. The rats were treated for ten consecutive weeks. The length of estrous cycle, reproductive indices, pregnancy outcomes, and number of postnatal deaths were recorded. At necropsy, organ weight was measured, gross and histopathological examinations of ovaries, uterus, and vagina were conducted.
UNASSIGNED: Treatment of rats, with high dose (1000 mg/kg) of S. guineense, significantly prolonged the duration of estrous cycle and reduced weight of uterus and ovaries as well as the number of total and live birth pups. However, there were no significant changes observed in reproductive indices and gross morphology as well as histopathology of ovaries, uterus, and vagina.
UNASSIGNED: Administration of high doses of S. guineense could be toxic to some aspects of the reproductive system of female rats and might also affect reproduction. Therefore, consuming high dose of S. guineense leaves is not recommended.
UNASSIGNED: Eighty female Wistar albino rats were randomly divided into four groups where each group consisted of 20 rats. Rats in the first three groups were treated with S. guineense extract at doses of 250, 500 and 1000 mg/kg body weight, respectively. The fourth group served as a control group. The rats were treated for ten consecutive weeks. The length of estrous cycle, reproductive indices, pregnancy outcomes, and number of postnatal deaths were recorded. At necropsy, organ weight was measured, gross and histopathological examinations of ovaries, uterus, and vagina were conducted.
UNASSIGNED: Treatment of rats, with high dose (1000 mg/kg) of S. guineense, significantly prolonged the duration of estrous cycle and reduced weight of uterus and ovaries as well as the number of total and live birth pups. However, there were no significant changes observed in reproductive indices and gross morphology as well as histopathology of ovaries, uterus, and vagina.
UNASSIGNED: Administration of high doses of S. guineense could be toxic to some aspects of the reproductive system of female rats and might also affect reproduction. Therefore, consuming high dose of S. guineense leaves is not recommended.
摘要：
■据报道，一些草药产品会影响繁殖。迄今为止,尽管该植物被广泛用于治疗与生育有关的问题，但尚未对其生殖毒性进行研究。因此，本研究的目的是研究70%的桂花叶乙醇提取物对雌性大鼠生殖功能和生殖器官组织病理学的毒性作用。
■将80只雌性Wistar白化病大鼠随机分为四组，每组20只大鼠。前三组的大鼠分别以250、500和1000mg/kg体重的剂量接受苦参提取物治疗，分别。第四组作为对照组。将大鼠连续治疗10周。发情周期的长度，生殖指数，妊娠结局,并记录了产后死亡人数。尸检时,测量器官重量，卵巢的大体和组织病理学检查，子宫,进行了阴道检查。
■大鼠的治疗，高剂量(1000毫克/千克)的几内亚，显着延长发情周期的持续时间，减少子宫和卵巢的重量以及总和活产幼崽的数量。然而,卵巢的生殖指数和大体形态以及组织病理学均无明显变化,子宫,还有阴道.
■服用高剂量的金丝雀可能对雌性大鼠生殖系统的某些方面有毒，也可能影响生殖。因此,不建议食用高剂量的S.guineense叶。
■将80只雌性Wistar白化病大鼠随机分为四组，每组20只大鼠。前三组的大鼠分别以250、500和1000mg/kg体重的剂量接受苦参提取物治疗，分别。第四组作为对照组。将大鼠连续治疗10周。发情周期的长度，生殖指数，妊娠结局,并记录了产后死亡人数。尸检时,测量器官重量，卵巢的大体和组织病理学检查，子宫,进行了阴道检查。
■大鼠的治疗，高剂量(1000毫克/千克)的几内亚，显着延长发情周期的持续时间，减少子宫和卵巢的重量以及总和活产幼崽的数量。然而,卵巢的生殖指数和大体形态以及组织病理学均无明显变化,子宫,还有阴道.
■服用高剂量的金丝雀可能对雌性大鼠生殖系统的某些方面有毒，也可能影响生殖。因此,不建议食用高剂量的S.guineense叶。
