Abstract：
CONCLUSIONS: We analyzed the evolutionary pattern of cysteine-rich peptides (CRPs) to infer the relationship between CRP copy number and plant ecotype, and the origin of bi-domains CRPs. Plants produce cysteine-rich peptides (CRPs) that have long-lasting broad-spectrum antimicrobial activity to protect themselves from various groups of pathogens. We analyzed 240 plant genomes, ranging from algae to eudicots, and discovered that CRPs are widely distributed in plants. Our comparative genomics results revealed that CRP genes have been amplified through both whole genome and local tandem duplication. The copy number of these genes varied significantly across lineages and was associated with the plant ecotype. This may be due to their resistance to changing pathogenic environments. The conserved and lineage-specific CRP families contribute to diverse antimicrobial activities. Furthermore, we investigated the unique bi-domain CRPs that result from unequal crossover events. Our findings provide a unique evolutionary perspective on CRPs and insights into their antimicrobial and symbiosis characteristics.
摘要：
结论：我们分析了富含半胱氨酸的肽（CRPs）的进化模式，以推断CRP拷贝数与植物生态型之间的关系，以及双结构域CRP的起源。植物产生富含半胱氨酸的肽（CRP），具有持久的广谱抗微生物活性，以保护自己免受各种病原体的侵害。我们分析了240个植物基因组,从藻类到eudicots，并发现CRPs在植物中广泛分布。我们的比较基因组学结果表明，CRP基因已通过全基因组和局部串联复制进行了扩增。这些基因的拷贝数在谱系之间显着变化，并且与植物生态型有关。这可能是由于它们对不断变化的致病环境的抵抗力。保守和谱系特异性CRP家族有助于多种抗菌活性。此外，我们调查了由不等交叉事件导致的独特的双域CRP。我们的发现为CRPs提供了独特的进化视角，并深入了解了它们的抗菌和共生特性。
