PDF(Pubmed)
Abstract：
Heparin is an anticoagulant which has been widely used in various clinical settings, from thromboprophylaxis to the treatment of thromboembolism. Heparin-induced thrombocytopenia (HIT) is a rare medical condition with severe complications if unrecognised, and it carries significant risks of co-morbidities and mortality. The incidence of HIT is relatively less common in low molecular weight heparin. HIT is more common in the venous system than the arterial circulatory system, and it is rare to see multi-vessel coronary artery thrombosis due to HIT. We hereby report a case of multi-vessel coronary thrombosis secondary to low molecular weight HIT, presenting as a case of ST-segment elevation myocardial infarction. We learned from the case that low molecular weight heparin can cause thrombosis secondary to HIT and HIT could be one of the differential diagnoses in those presenting with ST-elevation myocardial infarct and recent exposure to low molecular weight heparin.
摘要：
肝素是一种抗凝剂，已广泛用于各种临床环境，从血栓预防到血栓栓塞的治疗。肝素诱导的血小板减少症（HIT）是一种罕见的医学疾病，如果无法识别，则会出现严重的并发症，它具有共病和死亡的重大风险。HIT的发生率在低分子量肝素中相对较不常见。HIT在静脉系统比动脉循环系统更常见，很少看到由于HIT引起的多血管冠状动脉血栓形成。我们特此报告一例继发于低分子量HIT的多血管冠状动脉血栓形成，以ST段抬高型心肌梗死为例。我们从该病例中了解到，低分子量肝素可引起继发于HIT的血栓形成，HIT可能是ST段抬高心肌梗死和最近暴露于低分子量肝素的患者的鉴别诊断之一。
