PDF(Pubmed)
Abstract：
UNASSIGNED: Studies have shown the feasibility of short-course antimicrobials in complicated intra-abdominal infection (CIAI) following source control procedure (SCP). This study aimed to compare postoperative complication rates in short-course (5 days) and conventional (7-10 days) duration groups after antimicrobial therapy.
UNASSIGNED: This was a single-centre, open-labelled, randomised controlled trial conducted in Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India, from July 2017 to December 2019 on patients with CIAI. Patients who were haemodynamically unstable, pregnant and had non-perforated, non-gangrenous appendicitis or cholecystitis were excluded. Primary endpoints were surgical site infection (SSI), recurrent intra-abdominal infection (IAI) and mortality. Secondary endpoints included time till occurrence of composite primary outcomes, duration of antimicrobial therapy, the length of hospital stays, antimicrobial-free interval, hospital-free days at 30 day intervals and the presence of extra-abdominal infections.
UNASSIGNED: Overall, 140 patients were included whose demographic and clinico-pathological details were comparable in both groups. There was no difference in SSI (37% versus 35.6%) and recurrent IAI (5.7% versus 2.8%; P = 0.76); no mortality was observed in either groups. The composite primary outcome (37% versus 35.7%) was also similar in both groups. Secondary outcomes included the duration of antimicrobial therapy (5 versus 8 days; P <0.001) and length of hospitalisation (5 versus 7 days; P = 0.014) were significant. Times till occurrence of SSI and recurrent IAI, incidence of extra-abdominal infection and resistant pathogens were comparable.
UNASSIGNED: Short-course antimicrobial therapy for 5 days following SCP for mild and moderate CIAI was comparable to conventional duration antimicrobial therapy, indicating similar efficacy.
UNASSIGNED: This was a single-centre, open-labelled, randomised controlled trial conducted in Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India, from July 2017 to December 2019 on patients with CIAI. Patients who were haemodynamically unstable, pregnant and had non-perforated, non-gangrenous appendicitis or cholecystitis were excluded. Primary endpoints were surgical site infection (SSI), recurrent intra-abdominal infection (IAI) and mortality. Secondary endpoints included time till occurrence of composite primary outcomes, duration of antimicrobial therapy, the length of hospital stays, antimicrobial-free interval, hospital-free days at 30 day intervals and the presence of extra-abdominal infections.
UNASSIGNED: Overall, 140 patients were included whose demographic and clinico-pathological details were comparable in both groups. There was no difference in SSI (37% versus 35.6%) and recurrent IAI (5.7% versus 2.8%; P = 0.76); no mortality was observed in either groups. The composite primary outcome (37% versus 35.7%) was also similar in both groups. Secondary outcomes included the duration of antimicrobial therapy (5 versus 8 days; P <0.001) and length of hospitalisation (5 versus 7 days; P = 0.014) were significant. Times till occurrence of SSI and recurrent IAI, incidence of extra-abdominal infection and resistant pathogens were comparable.
UNASSIGNED: Short-course antimicrobial therapy for 5 days following SCP for mild and moderate CIAI was comparable to conventional duration antimicrobial therapy, indicating similar efficacy.
摘要：
■研究表明，在源控制程序（SCP）之后，短期使用抗生素在复杂的腹腔内感染（CIAI）中的可行性。这项研究旨在比较短期（5天）和常规（7-10天）抗菌治疗后的术后并发症发生率。
■这是一个单中心，开放标签，在Jawaharlal研究生医学教育和研究学院进行的随机对照试验，本地治里,印度,从2017年7月至2019年12月，CIAI患者。血液动力学不稳定的患者，怀孕了，没有穿孔，非坏疽性阑尾炎或胆囊炎被排除.主要终点是手术部位感染（SSI），复发性腹腔内感染（IAI）和死亡率。次要终点包括直到复合主要结局发生的时间，抗菌治疗的持续时间，住院时间的长短,无抗菌间隔，每隔30天不住院的天数和腹外感染的存在。
■总的来说，纳入140例患者，其人口统计学和临床病理细节在两组中具有可比性。SSI（37%对35.6%）和复发性IAI（5.7%对2.8%；P=0.76）无差异；两组均无死亡率。两组的复合主要结局(37%对35.7%)也相似。次要结果包括抗菌治疗的持续时间（5天对8天；P<0.001）和住院时间（5天对7天；P=0.014）。直到发生SSI和复发性IAI的次数，腹腔外感染和耐药病原体的发生率具有可比性.
■对于轻度和中度CIAI，在SCP之后进行5天的短期抗菌治疗与常规持续时间抗菌治疗相当，表明类似的功效。
■这是一个单中心，开放标签，在Jawaharlal研究生医学教育和研究学院进行的随机对照试验，本地治里,印度,从2017年7月至2019年12月，CIAI患者。血液动力学不稳定的患者，怀孕了，没有穿孔，非坏疽性阑尾炎或胆囊炎被排除.主要终点是手术部位感染（SSI），复发性腹腔内感染（IAI）和死亡率。次要终点包括直到复合主要结局发生的时间，抗菌治疗的持续时间，住院时间的长短,无抗菌间隔，每隔30天不住院的天数和腹外感染的存在。
■总的来说，纳入140例患者，其人口统计学和临床病理细节在两组中具有可比性。SSI（37%对35.6%）和复发性IAI（5.7%对2.8%；P=0.76）无差异；两组均无死亡率。两组的复合主要结局(37%对35.7%)也相似。次要结果包括抗菌治疗的持续时间（5天对8天；P<0.001）和住院时间（5天对7天；P=0.014）。直到发生SSI和复发性IAI的次数，腹腔外感染和耐药病原体的发生率具有可比性.
■对于轻度和中度CIAI，在SCP之后进行5天的短期抗菌治疗与常规持续时间抗菌治疗相当，表明类似的功效。
