PDF(Pubmed)
Abstract：
The Costa Rican pygmy rice rat (Oligoryzomys costaricensis) is the primary reservoir of Choclo orthohantavirus (CHOV), the causal agent of hantavirus disease, pulmonary syndrome, and fever in humans in Panama. Since the emergence of CHOV in early 2000, we have systematically sampled and archived rodents from >150 sites across Panama to establish a baseline understanding of the host and virus, producing a permanent archive of holistic specimens that we are now probing in greater detail. We summarize these collections and explore preliminary habitat/virus associations to guide future wildlife surveillance and public health efforts related to CHOV and other zoonotic pathogens. Host sequences of the mitochondrial cytochrome b gene form a single monophyletic clade in Panama, despite wide distribution across Panama. Seropositive samples were concentrated in the central region of western Panama, consistent with the ecology of this agricultural commensal and the higher incidence of CHOV in humans in that region. Hantavirus seroprevalence in the pygmy rice rat was >15% overall, with the highest prevalence in agricultural areas (21%) and the lowest prevalence in shrublands (11%). Host-pathogen distribution, transmission dynamics, genomic evolution, and habitat affinities can be derived from the preserved samples, which include frozen tissues, and now provide a foundation for expanded investigations of orthohantaviruses in Panama.
摘要：
哥斯达黎加侏儒稻鼠（Oligoryzomyscostaricensis）是Choclo正坦病毒（CHOV）的主要宿主，汉坦病毒病的病因,肺综合征,巴拿马的人类发烧。自2000年初出现CHOV以来，我们系统地对巴拿马150多个地点的啮齿动物进行了采样和存档，以建立对宿主和病毒的基线了解，制作一个永久性的整体标本档案，我们现在正在更详细地探索。我们总结了这些集合，并探索了初步的栖息地/病毒关联，以指导未来与CHOV和其他人畜共患病原体相关的野生动物监测和公共卫生工作。线粒体细胞色素b基因的宿主序列在巴拿马形成一个单一的单系进化枝，尽管在巴拿马分布广泛。血清阳性样本集中在巴拿马西部的中部地区，与该农业共生的生态以及该地区人类CHOV的较高发病率一致。侏儒稻鼠的汉坦病毒血清阳性率总体上>15%，农业区患病率最高(21%)，灌木丛患病率最低(11%)。宿主-病原体分布，传输动力学，基因组进化，栖息地亲和力可以从保存的样本中获得，其中包括冷冻组织，现在为扩大巴拿马正端病毒的调查提供了基础。
