PDF(Pubmed)
Abstract：
In a mutually beneficial connection with its host, the gut microbiota affects the host\'s nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types of disease and gut dysbiosis or specific microorganisms. Fecal microbiota transplantation (FMT) is strongly advised for the treatment of recurrent or resistant Clostridium difficile infection (CDI) due to its outstanding clinical effectiveness against CDI. The therapeutic potential of FMT for other disorders, particularly inflammatory bowel diseases and malignancies, is currently gaining more and more attention. We summarized the most recent preclinical and clinical evidence to show the promise of FMT in the management of cancer as well as complications related to cancer treatment after reviewing the most recent research on the gut microbiota and its relationship to cancer.
摘要：
在与宿主的互利联系中，肠道微生物群影响宿主的营养，豁免权,和新陈代谢。越来越多的研究表明，某些类型的疾病与肠道生态失调或特定微生物之间存在联系。由于粪便微生物群移植（FMT）对CDI具有出色的临床疗效，因此强烈建议用于治疗复发性或耐药性艰难梭菌感染（CDI）。FMT对其他疾病的治疗潜力，特别是炎症性肠病和恶性肿瘤，目前正在获得越来越多的关注。在回顾了有关肠道微生物群及其与癌症的关系的最新研究之后，我们总结了最新的临床前和临床证据，以显示FMT在癌症治疗以及与癌症治疗相关的并发症方面的前景。
